舍曲林联合重复经颅磁刺激低频刺激右侧腹内侧前额叶皮质（VMPFC）治疗青少年抑郁症的非自杀性自伤行为（NSSI）的临床研究
A clinical study of low frequency rTMS stimulation in the right ventromedial prefrontal cortex(VMPFC) combined with Sertraline on the treatment of the adolescents with nonsuicidal self-injurious behaviors
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2021, 48(6) |
| 作者 |
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| 作者单位 |
四川省自贡市精神卫生中心 ;
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| 摘要 |
探讨重复经颅磁刺激对青少年抑郁症中非自杀性自伤行为的疗效，优势及应用前景。 方法 选择36例伴有非自杀性自伤行为的青少年抑郁症患者，随机分为单一药物治疗组（n=18），rTMS联合药物治疗组（n=18），于治疗前、治疗后2周末进行HAMD评定临床疗效、BIS-II评定冲动情绪水平、自我伤害行为筛选量表评估其外显行为、TESS评定不良反应。结果 2周末，rTMS联合药物治疗组患者抑郁症治疗有效率为84.6%，单一药物组有效率为38.9%，两组差异有统计学意义（P＜0.05）。2周末rTMS联合药物治疗组较单一药物治疗组, HAMD总分及各因子分（F=249.35、301.03、25.69、34.87、2.95、151.31、64.33、41.81）均有明显下降（P＜0.05），BIS-II总分及各项因子分（注意因子、运动因子、缺乏计划因子）（t=3.841、3.410、2.863.3.372），自我伤害行为筛选量表总分及忧郁孤独因子分、自残自杀因子分、退缩与自我批评因子分也均有明显下降（t=3.341、3.293、2.817、2.234）（P均＜0.05）。结论 低频重复经颅磁刺激联合药物治疗不仅可以尽快改善抑郁症状，而且能降低自伤自杀行为的风险，不良反应少，安全性高。
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| Abstract |
Objective To investigate the effects, advantages and application prospects of low frequency rTMS in the right ventromedial prefrontal cortex(VMPFC) combined with Sertraline on the treatment of the adolescents with nonsuicidal self-injurious behaviors. Methods 36 patients were collected. They were randomly divided into medication group (18 cases) and medication combined with rTMS group (18 cases)．The Clinical curative effects were assessed using HAMD(Hamilton Depression Scale) before treatment and 2 weeks after treatment while we used the Barratt Impulsiveness Scale,11th Version(BIS-11) assessing the emotional lability and impulsiveness and the Self-injurious Behavior Screening Scale evaluating the overt behaviors. Adverse reaction was assessed after treatment with TESS. Results The effective rate was 84.6% in the rTMS group while 38.9% in the medication group (P<0.05) at the end of 2nd
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| 关键词 |
青少年抑郁症；非自杀性自伤行为；重复经颅磁刺激；腹内侧前额叶皮质
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| KeyWord |
Nonsuicidal self-injurious；Repetitive transcranial magnetic stimulation；Ventromedial prefrontal cortex.
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| 基金项目 |
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| 页码 |
987-990 |
余寒*.
舍曲林联合重复经颅磁刺激低频刺激右侧腹内侧前额叶皮质（VMPFC）治疗青少年抑郁症的非自杀性自伤行为（NSSI）的临床研究 [J].
国际精神病学杂志.
2021; 48; (6).
987 - 990.