Journal of International Psychiatry

[Abstract] Objective To discuss the comparison of the efficacy of dexzopiclone and estazolam in senile dementia with sleep disorders. Methods Eighty-six patients with dementia and sleep disorders from February 2018 to February 2020 were included in this study as the subjects, and were randomly divided into the control group and the observation group. The control group was treated with estazolam, and the observation group was treated with dexzopiclone. Before and after treatment, the Pittsburgh sleep index scale (PSQI), vitality scale (ADL), mini-mental state examination (MMSE), and Pathological behavior score (BEHA VE-AD) were evaluated. The occurrence of adverse reactions were compared. Results The PSQI score of the two groups decreased significantly after treatment, and the ADL score and MMSE score increased significantly. After treatment, the MMSE score and BEHA VE-AD score of the observation group were better than those of the control group (P<0.05). There was no significant difference in PSQI score between the two groups (P>0.05). The scores of each dimension of the BEHA VE-AD scale of the two groups were significantly reduced after treatment, and the observation group was significantly lower than the control group after treatment (P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P>0.05). Conclusion Ezopiclone and estazolam have the same effect in improving Alzheimers disease with sleep disorders, but dexzopiclone not only has a low incidence of adverse reactions, but also helps to improve patients cognitive function and mobility.

Key words Dexzopiclone; Estazolam; Alzheimers Disease; Sleep Disorders