Journal of Modern Nursing MedicineJPCNS

Objective To analyze the effects of different doses of aspirin and Plavix on platelet aggregation function and nursing effect in patients with aspirin resistance. Methods Patients with aspirin resistance treated in the hospital during two years (sample inclusion time: July 2021 to July 2024; sample inclusion number: 84 cases) were selected as research subjects and divided into control group (100 mg aspirin + Plavix treatment combined with routine care, n=42) and study group (300 mg aspirin + Plavix treatment combined with evidence-based care, n=42). The platelet aggregation function, medication compliance, self-efficacy and quality of life of the two groups were compared. Results There was no significant difference between the two groups in the platelet aggregation rate induced by adenosine dicarbonate and the platelet aggregation rate induced by arachidonic acid (P＞0.05). The study group had higher scores in medication compliance, self-efficacy and quality of life than the control group (P < 0.05). Conclusion Different doses of aspirin + Plavix have similar effects on improving platelet aggregation function in patients with aspirin resistance. Evidence-based nursing can improve medication compliance and quality of life, and can be further promoted and applied in clinical practice.

Aspirin resistance; Evidence-based nursing; Platelet aggregation function; Medication compliance