| Abstract |
[Abstract] Objective To study the effect of risperidone, quetiapine, clozapine and olanzapine on the prolongation of QTc interval in elderly schizophrenia.Methods 132 elderly schizophrenic patients in our hospital were selected as the research objects, and they were randomly divided into 4 groups, 33 cases in each group. Risperidone, quetiapine, clozapine and olanzapine were used in the four groups. The general data of the four groups were compared, and the changes of QTc before treatment and at 1, 3 and 6 months after treatment were analyzed. The QTc prolongation of 6 months after treatment was compared with that before treatment. The differences of QTc interval prolongation between the four groups of patients with different genders were compared, and the changes of electrolyte blood potassium, serum sodium and blood magnesium levels before and after treatment were analyzed.Results The QTc interval of risperidone group, quetiapine group and olanzapine group at 3 and 6 months after treatment was significantly longer than that before treatment（P＜0.05）, and that of clozapine group at 6 months was significantly longer than that before treatment（P＜0.05）;The QTc interval of clozapine group was significantly lower than that of quetiapine group（P＜0.05）, while that of clozapine group and olanzapine group was significantly lower than that of risperidone group and quetiapine group（P＜0.05）.The QTc interval prolongation in risperidone group and quetiapine group was significantly higher than that in male group（P＜0.05）, while the QTc interval prolongation in clozapine group and olanzapine group was significantly lower than that in risperidone group and quetiapine group（P＜0.05）.There was no significant difference in serum potassium, sodium and magnesium levels between the four groups before and after treatment（P＞0.05）.Conclusion Risperidone, quetiapine, clozapine and olanzapine in the treatment of senile schizophrenia have a certain impact on QTc interval prolongation, risperidone and quetiapine have a greater impact, and women have a higher risk of QTc interval extension, but the overall impact is limited.
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