Journal of International Psychiatry

[Abstract] Objective: To investigate the efficacy of venlafaxine sustained release agent and paroxetine in the treatment of female depression with anxiety and its influence on the mental state of the patients. Methods: 80 female patients with depression complicated with anxiety from February 2018 to February 2020 were randomly divided into two groups. 40 patients in the control group were treated with paroxetine. 40 patients in the observation group were treated with venlafaxine sustained release agent. The effective rate before and after treatment, the improvement of HAMA, HAMD score, MoCA cognitive function score and the occurrence of adverse reactions before and after treatment were statistically analyzed. Results: the scores of HAMA and HAMD in the observation group were lower than those in the control group, and the effective rate in the observation group was higher than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05), and there was no significant difference in the improvement of cognitive function between the two groups (P>0.05). Conclusion: Venlafaxine sustained release agent is better than paroxetine in the treatment of female depression with anxiety, which can effectively improve anxiety and depression and other adverse emotions. The total effective rate is relatively high, but there is no significant difference in adverse reactions and cognitive function between the two drugs.

Keywords: female; depression; anxiety; venlafaxine sustained release agent; paroxetine; mental state