食管癌免疫治疗过程中发生巨细胞病毒食管炎1例并回顾文献-科学发展研究-CSCIED科技核心评价数据库-手机版

食管癌免疫治疗过程中发生巨细胞病毒食管炎1例并回顾文献

A case of cytomegalovirus esophagitis during immunotherapy for esophageal cancer and a review of the literature

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DOI	10.12208/j.sdr.20250005
刊名	科学发展研究 Scientific Development Research
年，卷(期)	2025, 5(1)
作者	王晓辉^1,2,周瑞^1,2,张盛^1,2*,
作者单位	1 华中科技大学同济医学院附属协和医院肿瘤中心湖北武汉 2 华中科技大学同济医学院附属协和医院放射肿瘤研究所湖北武汉
摘要	本研究报道了一例晚期食管癌患者在卡瑞利珠单抗免疫维持治疗期间发生巨细胞病毒食管炎的病例，并对相关文献进行了回顾。患者在接受卡瑞利珠单抗治疗14次后出现发热、吞咽痛、吞咽困难，经胃镜检查和病理活检确诊为巨细胞病毒食管炎。给予更昔洛韦抗病毒治疗后症状缓解，CMV抗原血症转为阴性，食道溃疡改善。本病例强调了在食管癌免疫治疗过程中需警惕巨细胞病毒食管炎这一罕见但严重的并发症。
Abstract	This study reports a case of cytomegalovirus esophagitis in a patient with advanced esophageal cancer during maintenance immunotherapy with carrelizumab, and reviews the relevant literature. The patient developed fever, odynophagia, and dysphagia after 14 treatments with carrelizumab, and was diagnosed with cytomegalovirus esophagitis by gastroscopy and pathological biopsy. After antiviral treatment with ganciclovir, the symptoms were relieved, CMV antigenemia became negative, and esophageal ulcers improved. This case emphasizes the need to be vigilant against cytomegalovirus esophagitis, a rare but serious complication during immunotherapy for esophageal cancer.
关键词	食管癌；放射治疗；巨细胞病毒；病例报告
KeyWord	Esophageal cancer; Radiotherapy; Cytomegalovirus; Case report
基金项目
页码	24-27

参考文献
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引用本文

王晓辉^,,周瑞^,,张盛^,*. 食管癌免疫治疗过程中发生巨细胞病毒食管炎1例并回顾文献 [J]. 科学发展研究. 2025; 5; (1). 24 - 27.

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