Journal of International Psychiatry

Schizophrenia is a mental disorder with complex pathogenesis and high prevalence rate. Oxidative stress plays an important role in the pathological process of schizophrenia. By detecting the levels of oxidative stress biomarkers in peripheral blood and cerebrospinal fluid, it can be observed that schizophrenia patients generally have REDOX imbalance, and the application of antioxidants can reduce oxidative stress injury and alleviate some clinical symptoms. Oxidative stress may lead to a series of schizophrenic symptoms by inducing neuroinflammatory, impairing the maturation process of oligodendrocyte precursor cells, reducing the functional activity of N-methyl-D-aspartate receptor, and damaging parvalbumin interneurons during the critical period of neural development.

Schizophrenia；Oxidative stress；Pathological mechanism