Journal of International Psychiatry

【Abstract】Objective To investigate the effect of fluoxetine treatment in patients with post-stroke depression and analyze its influence on negative emotions and neurological function. Methods 131 patients with post-stroke depression admitted to our hospital from January 2018 to June 2020 were included as observation objects. They were divided into 2 groups by coin toss. Both groups received conventional basic treatment, and 65 patients in the control group were added With psychological intervention, 66 patients in the observation group were treated with fluoxetine orally on the basis of the control group, and the serum factor levels, neurological function, depression and treatment compliance of the two groups were compared. Results After treatment, the serum factors of the two groups were compared. The Hcy, NSE and S100-β of the observation group were significantly lower than those of the control group, and the difference was significant (P<0.05); the observation groups NIHSS score and HAMD score were significantly lower than the control group , And the treatment compliance of the observation group was higher than that of the control group, the difference was significant (P<0.05). Conclusion Fluoxetine can significantly reduce the neurological deficit in patients with post-stroke depression, improve the neurological function of the patients, relieve the depression of the patients, and improve the compliance of clinical treatment. It is worth recommending.

[Keywords] fluoxetine; post-stroke depression; negative emotions; neurological function; psychological intervention