Journal of International Psychiatry

[Abstract] Objective To analyze the effects of dexmedetomidine intervention on elderly patients undergoing total hip replacement surgery on postoperative delirium and inflammation. Methods 87 elderly patients who underwent total hip arthroplasty in our hospital were divided into a control group (45 cases) and an experimental group (42 cases) by a single blind method. The control group was given intravenous pumping before anesthesia and during the operation. Saline, while the experimental group was injected with dexmedetomidine intravenously before anesthesia. The indicators related to surgery and recovery, cognitive function, inflammatory response, postoperative delirium and adverse reactions were compared between the two groups of patients. Results There was no significant difference in operation time, intraoperative blood loss, and incidence of adverse reactions between the two groups (P>0.05); the propofol dosage and recovery time of the experimental group were lower than those of the control group, and the difference was statistically significant (P<0.05) ; Compared with the control group, the MMSE score of the experimental group increased significantly after 6 hours after surgery, and the levels of inflammatory factors such as TNF-α, IL-18, and CRP were significantly reduced (P<0.05); the incidence of postoperative delirium in the experimental group was low In the control group (P<0.05).Conclusion The intervention of dexmedetomidine in elderly patients undergoing total hip arthroplasty can reduce the amount of anesthetic drugs and shorten the recovery time, which can reduce the impact on patients cognitive function, reduce the incidence of postoperative delirium, and inhibit inflammation reaction.

[Key words] Total hip replacement; Dexmedetomidine; Delirium; Inflammation