丁苯酞治疗脑梗死后抑郁疗效及对血清炎性因子水平的影响
Effect of Butylphthalide on Depression after Cerebral Infarction and Its Influence on Serum Inflammatory Factors
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2021, 48(4) |
| 作者 |
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| 作者单位 |
南阳医学高等专科学校第一附属医院临床药学科 ;
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| 摘要 |
【摘要】探讨丁苯酞治疗脑梗死后抑郁疗效及对血清炎性因子水平的影响。方法 本研究对象为我院2018年8月~2020年8月100例脑梗死后抑郁患者，随机分为对照组与观察组，对照组接受常规神经内科治疗并给予舍曲林进行抗抑郁治疗，观察组在对照组基础上联合丁苯酞治疗。比较治疗前后汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、运动功能评定量表（Fugl-Meyer）、美国国立卫生研究院卒中量表（NIHSS），检测治疗前后血清白细胞介素-6( IL-6)、IL-8以及 C反应蛋白(CRP)水平。结果 两组治疗后各项评分均显著改善，且治疗后观察组HAMD评分、HAMA评分、NIHSS评分均显著低于对照组，Fugl-Meyer评分显著高与对照组，（P<0.05）；两组治疗后血清IL-6、IL-8以及CRP水平均显著降低，且治疗后观察组显著低于对照组，（P<0.05）。结论 丁苯酞治疗脑梗死后抑郁能有效改善患者焦虑、抑郁情绪，并帮助患者提升神经及运动功能，降低血清炎性因子水平。
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| Abstract |
[Abstract] Objective To investigate the efficacy and effects of buphthalein on serum levels of inflammatory factors in treatment of post cerebral infarction depression. Methods A total of 100 patients with post cerebral infarction depression from August 2018 to August 2020 in our hospital were the subjects of this study, and randomly divided into a control group and an observation group. The control group received routine neurology treatment and was given sertraline for antidepressant treatment, and the observation group was combined with buphthalein treatment on a control group basis.The Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), motor function rating scale (Fugl Meyer), national institutes of health stroke scale (NIHSS) were compared before and after treatment, and serum levels of interleukin-6 (IL-6), IL-8 as well as C-reactive protein (CRP) were detected. Results All scores were significantly improved after treatment in both groups, and the HAMD score, HAMA score, and NIHSS score were significantly lower in the observation group than in the control group after treatment, with significantly higher Fugl Meyer scores compared with the control group (P < 0.05).Serum levels of L-6, IL-8 as well as CRP were significantly decreased in both treatment groups and were significantly lower in the observation group after treatment than in the control group (P < 0.05). Conclusion Buphthalein treatment of post cerebral infarction depression can effectively improve patients anxiety and depression, and help patients to improve their neurological and motor functions and reduce serum levels of inflammatory factors.
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| 关键词 |
关键词：丁苯酞;脑梗死后抑郁;血清炎性因子;神经功能；运动功能
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| KeyWord |
Keywords Buphthalein; Post Cerebral Infarction Depression; Serum Inflammatory Factors; Neurological Function; Motor Function
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| 基金项目 |
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| 页码 |
681-683 |
王米香*.
丁苯酞治疗脑梗死后抑郁疗效及对血清炎性因子水平的影响 [J].
国际精神病学杂志.
2021; 48; (4).
681 - 683.