| Abstract |
[Abstract]Objective: To investigate the relationship between serum magnesium (Mg2+) and post-stroke depression (PSD) and the effect of paroxetine treatment on it. Methods: From January 2018 to September 2020, 82 PSD patients (observation group) were selected, and 164 patients without depression after stroke were selected as the control group, the difference of clinical data between the two groups was analyzed; the observation group was treated with paroxetine, and the serum Mg2+ and Hamilton Depression Scale (HAMD) scores before and after treatment were observed. Results: The proportion of females, years of education, proportion of cerebral hemorrhage and NIHSS score in the observation group were 64.63%, (11.20±2.80) years, 47.56% and (7.02±1.55) points, which were significantly higher than the control group (p < 0.05), while the serum Mg2+ was (0.80±0.08) mmol/L, which was significantly lower than the control group (p < 0.05); The HAMD score of the observation group was (12.20±3.40); Serum Mg2+ was negatively correlated with HAMD score (r=-0.378, p < 0.05);The results of Logistic regression analysis showed that female, intracranial hemorrhage, NIHSS score and serum Mg2+ were the influencing factors for the occurrence of PSD (OR=1.725, 1.944, 2.038 and 0.642, p < 0.05); The serum Mg2+ in the observation group after treatment was (0.86±0.09) mmol/L, which was higher than that before treatment (p < 0.05), while the HAMD score was (7.10±1.22), which was lower than that before treatment (p < 0.05). Conclusion: Serum Mg2+ is the influencing factor of PSD, and paroxetine treatment can significantly improve serum Mg2+ level.
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