International Medical Research Frontier

Objective To evaluate the clinical efficacy of Niuhuang Jiedu soft capsules combined with levofloxacin eye drops in the treatment of patients with acute conjunctivitis. Methods A total of 72 patients with acute conjunctivitis were included in this study and divided into a control group and an experimental group. There were no statistically significant differences in baseline data such as gender, age, location of disease onset, and duration of illness between the two groups (P>0.05). Patients in the control group were treated only with levofloxacin eye drops, while patients in the experimental group were additionally administered Niuhuang Jiedu soft capsules on top of the levofloxacin eye drops treatment, with a treatment duration of 7 days. The clinical efficacy was assessed by comparing the symptoms before and after treatment, such as pharyngeal pain, eye irritation, eye itching, corneal secretion, conjunctival congestion, and white eye swelling, as well as serum inflammatory factors and tear indicators. Results After the treatment, the clinical effective rate of the experimental group reached 97.2%, which was significantly higher than the 86.2% of the control group. The chi-square test indicated that the difference was statistically significant (P<0.05). Both groups showed improvement in symptoms after treatment, with the experimental group showing a significant reduction in all symptoms except conjunctival congestion when compared to the control group, and the differences were statistically significant (P<0.01). Moreover, the serum inflammatory factors (IL-8 and TNF-α) and tear indicators (HA and IgE) in the experimental group were significantly lower than those in the control group after treatment, with statistically significant differences (P<0.01). Conclusion The combined treatment of Niuhuang Jiedu soft capsules and levofloxacin eye drops for acute conjunctivitis demonstrates significant clinical efficacy.

Niuhuang Jiedu soft capsules; Levofloxacin; Acute Conjunctivitis; Heat-clearing and Detoxifying; Wind-heat obstructing the eyes