基于古代文献数据挖掘的哮喘用药特点和规律研究

Study on the characteristics and regularity of asthma medication based on data mining of ancient literature

ES评分 0

DOI 10.12208/j.ijmd.20250004
刊名
International Journal of Medicine and Data
年,卷(期) 2025, 9(1)
作者
作者单位

华北理工大学中医学院 河北唐山

摘要
目的 分析《中华医典》中治疗哮喘的方剂,研究其用药特点和规律,为临床治疗哮喘提供借鉴。方法 将符合条件的方剂纳入数据库,借助Excel 2021进行频数分析,使用SPSS modeler 18.0、lantern 5.0进行关联规则分析和隐结构分析,从多角度探讨古文献中治疗哮喘的用药特点和规律。结果 共收录455首方剂,总用药频次3415次,中药326味,甘草、半夏、茯苓、杏仁出现频次高。药性以温性为主,寒性、热性次之。药味多甘、辛、苦。归经多归肺、脾、肾经。共得出25条强关联规则,其中茯苓-白术、半夏-陈皮-甘草为主要的强关联规则。共得出11个隐变量,4类综合聚类,4组核心方剂,继而推断出四组哮喘的证型分别为肾虚型,寒饮内停型,脾虚湿盛型,痰浊阻肺型。结论 古代文献中治疗哮喘的方剂主要有四个核心证型,其中痰浊阻肺型哮喘贡献值较大。治疗哮喘时宜分别辩证使用补肝肾,温肺化饮,燥湿健脾,祛痰类中药。
Abstract
Objective To analyze the prescriptions for the treatment of asthma in the Chinese Medical Code, and to study the characteristics and rules of their use, so as to provide reference for the clinical treatment of asthma. Methods The eligible prescriptions were included in the database, frequency analysis was performed by Excel 2021, association rule analysis and implicit structure analysis were performed by SPSS modeler 18.0 and lantern 5.0, and the characteristics and rules of medication used in ancient literature for asthma were discussed from multiple perspectives. Results A total of 455 prescriptions were included, the total frequency of use was 3415 times, and 326 herbs, licorice, pinellia, Tuckaia, almond appeared frequently. The drug properties were mainly warm, followed by cold and heat. The medicine tastes sweet, bitter and bitter. Return to the lung, spleen, kidney channels. A total of 25 strong association rules were obtained, among which the main strong association rules were Tuckahoe White Rhizoma, Pinellia pinellia, orange peel and licorice. A total of 11 hidden variables, 4 types of comprehensive clustering, four groups of core prescriptions, and then inferred that the four groups of asthma syndromes were kidney deficiency, cold drink internal stopping, spleen deficiency and dampness, phlegm turbidification and lung obstruction. Conclusion There are four core syndromes in the prescription of asthma in ancient literature, and the contribution of phlegm-turbidity-obstructed asthma is greater. The treatment of asthma should be dialectically used to supplement the liver and kidney, warm the lung and Hua Yin, dry dampness and spleen, expectorant TCM.
关键词
哮喘;隐结构;关联规则分析;用药规律
KeyWord
Asthma; Hidden structure; Association rules analysis; Drug rule
基金项目
页码 20-29
  • 参考文献
  • 相关文献
  • 引用本文

张旭,孟梓涵,成杭洁,李贺祎,任明聪,马欣宇,仇海岩,虞跃跃*. 基于古代文献数据挖掘的哮喘用药特点和规律研究 [J]. 国际医学与数据杂志. 2025; 9; (1). 20 - 29.

  • 文献评论

相关学者

相关机构