血清BDNF、Ghrelin水平与冠心病合并抑郁的关系探讨
Study on the Relationship Between Serum BDNF, Ghrelin Levels and Coronary Heart Disease Complicated with Depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2022, 49(1) |
| 作者 |
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| 作者单位 |
河南省直属机关第一门诊部心血管内科 ;
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| 摘要 |
摘要 目的：探讨血清脑源性神经营养因子（BDNF）、胃饥饿素（Ghrelin）与冠心病合并抑郁的关系。方法：选择2019年2月-2021年2月106例冠心病患者为研究对象，采用汉密尔顿抑郁量表（HAMD）进行抑郁筛查，并设为抑郁组（重度组10例、中度组15例，轻度组17例）以及无抑郁组，分别为42例，64例，比较各组血清BDNF、Ghrelin水平，采用Pearson 相关分析血清BDNF、Ghrelin水平与HAMD评分的关系，通过绘制ROC曲线判断血清BDNF、Ghrelin水平对冠心病合并抑郁诊断价值。结果：抑郁组血清BDNF、Ghrelin水平显著低于无抑郁组，重度组血清BDNF、Ghrelin水平显著低于中度组，中度组显著低于轻度组，（P<0.05）；血清BDNF、Ghrelin水平与HAMD评分呈显著负相关关系，（P<0.05）；ROC曲线显示，血清BDNF、Ghrelin水平诊断冠心病合并抑郁AUC值为0.99、0.93，临界值为0.15、0.24，敏感性为98.66%、95.23%,特异性为 97.34%、 84.40%。结论：血清BDNF、Ghrelin水平与冠心病合并抑郁关系密切，与抑郁严重程度呈负相关关系，对冠心病合并抑郁具有一定的诊断价值。
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| Abstract |
[Abstract] Objective To explore the relationship between serum brain-derived neurotrophic factor (BDNF), ghrelin (Ghrelin) and coronary heart disease complicated with depression. Methods From February 2019 to February 2021, 106 patients with coronary heart disease were selected as the research objects, and the Hamilton Depression Scale (HAMD) was used for depression screening, and set as the depression group (10 cases in the severe group, 15 cases in the moderate group, and mild). (17 cases in the degree group) and the non-depression group, 42 cases and 64 cases respectively. Compare the levels of serum BDNF and Ghrelin in each group. Pearson correlation analysis was used to analyze the relationship between serum BDNF, Ghrelin levels and HAMD score. The ROC curve was drawn to determine the value of serum BDNF and Ghrelin levels in the diagnosis of coronary heart disease complicated with depression. Results The levels of serum BDNF and Ghrelin in the depression group were significantly lower than those of the non-depression group, the levels of serum BDNF and Ghrelin in the severe group were significantly lower than those in the moderate group, and the moderate group were significantly lower than the mild group (P<0.05). Serum BDNF and Ghrelin levels were significantly negatively correlated with HAMD scores (P<0.05). The ROC curve showed that the AUC values of serum BDNF and Ghrelin levels for the diagnosis of coronary heart disease complicated with depression were 0.99 and 0.93, the cut-off values were 0.15 and 0.24, the sensitivity was 98.66% and 95.23%, and the specificity was 97.34% and 84.40%. Conclusion Serum BDNF and Ghrelin levels are closely related to coronary heart disease complicated with depression, and negatively correlated with the severity of depression, and have certain diagnostic value for coronary heart disease complicated with depression.
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| 关键词 |
关键词：冠心病;抑郁;脑源性神经营养因子;胃饥饿素
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| KeyWord |
Key words Coronary Heart Disease; Depression; Brain-Derived Neurotrophic Factor; Ghrelin
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| 基金项目 |
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| 页码 |
87-89 |
程保玲*.
血清BDNF、Ghrelin水平与冠心病合并抑郁的关系探讨 [J].
国际精神病学杂志.
2022; 49; (1).
87 - 89.