BALF细胞形态学检查与外周血WBC分类计数在肺部感染中的相关性研究及价值探讨-国际医学与数据杂志-CSCIED科技核心评价数据库-手机版

BALF细胞形态学检查与外周血WBC分类计数在肺部感染中的相关性研究及价值探讨

A study on the correlation and value of BALF cell morphological examination and peripheral blood WBC differential count in pulmonary infection

ES评分 0 浏览量：99 下载量：0

全文阅读下载引用收藏

DOI	10.12208/j.ijmd.20250040
刊名	国际医学与数据杂志 International Journal of Medicine and Data
年，卷(期)	2025, 9(2)
作者	张莹桃*,黎华连,欧红娟,蔡名娟,卢宇,谢祖林,
作者单位	柳州市人民医院检验科广西柳州
摘要	肺部感染是一种临床常见的感染性疾病，并发于各类术后和肺部疾病，会导致咳嗽、咳痰、胸痛、呼吸困难，如果病情不能得到缓解，甚至会导致患者死亡，因此及时的诊治对患者尤为重要。血细胞检查中白细胞分类、粒淋比等指标的变化能够很好地反映患者体内病原菌情况及免疫功能状态，为判断机体肺部感染情况的重要指标之一。而支气管肺泡灌洗液（bronchoaveolar lavage fluid.BALF）是通过病变部位的直接取材，通过其进行相关检查能更好的反映肺部病变情况。故本文对BALF细胞形态学检查与外周血WBC分类在肺部感染中的相关性研究的新进展进行综述。
Abstract	Pulmonary infection is a common clinical infectious disease that often occurs after various surgeries and in patients with lung diseases. It can cause cough, expectoration, chest pain, and shortness of breath. If the condition is not relieved in time, it may even lead to death. Therefore, timely diagnosis and treatment are particularly important for patients. Changes in indicators such as white blood cell classification and granulocyte-lymphocyte ratio in blood cell tests can well reflect the pathogen situation and immune function status in the patients body, and are one of the important indicators for judging the condition of pulmonary infection. Bronchoalveolar lavage fluid (BALF) is obtained directly from the lesion site, and related tests through it can better reflect the lung lesion situation. Therefore, this article reviews the new progress in the correlation research between BALF cell morphology examination and peripheral blood WBC classification in pulmonary infection.
关键词	肺部感染；白细胞分类计数；BALF细胞形态学检查；肺泡灌洗液
KeyWord	Lung infection; Leukocyte classification count; BALF cell morphology examination; BALF
基金项目
页码	92-92

参考文献
相关文献

[1] Hare KM,Marsh RL,Smith-Vaughan HC,et al.Respirato-rybacterial culture from two sequential bronchoalveolar lava-ges of the same lobe in children with chronic cough
[J].J MedMicrobiol,2015,64 (11):1353-1360.
[2] 杜鹃,罗健.支气管肺泡灌洗液检查在儿童呼吸疾病中的应用研究进展
[J].现代医药卫生,2019,35(23):3637-3641.
[3] Arrieta O, Nunez-Valencia C, Reynoso-Erazo L, et al. Related quality of life in patients with lung cancer: Validati on of the Mexican-Spanish version and association with prognosis of the EORTC QLQ-LCI3 questionnaire
[J]. Lung Cancer, 2012, 77 (1) :205-211.
[4] 中华医学会呼吸病学分会.支气管肺泡灌洗液细胞学检测技术规范 (草案)
[J].中华结核和呼吸杂志, 2002, 25 (7) :390-391.
[5] Danila E, Jurqauskiene L, Norkuniene J, et al. BALfluid cells in newly diagnosed pulmonary sarcoidosiswith different clinical activity
[J]. Ups J Med Sci, 2009, 114 (1) :26-31.
[6] Domagaa-Kulawik J, Guzman J, Costabel U. Immunecells in bronchoalveolar lavage in peripheral lungcancer-analysis of 140 cases
[J]. Respiration, 2003, 70 (1) :43-48.
[7] 周道银,吴茅,许绍强,张时民,樊爱琳,黄道连,高建军,朱凤娇,闫立志,刘超群,柏世玉,曹科,窦心灵,丁邦胜,段爱军,高菊兴,顾剑飞,高海燕,何勇,黄俊,胡晶,蒋锦文,金鑫,卢兴国,李相磊,梁勤,林慧君,缪峰,潘巍,茹进伟,孙宏华,王敏敏,王哲,夏万宝,邢铭芬,许银怀,岳保红,张建富,张军格,曾强武,赵成艳,庄顺红,周玉利,郑智弦,周麟,郑瑞.支气管肺泡灌洗液细胞形态学检验中国专家共识(2020)
[J].现代检验医学杂志,2020,35(06):4-8.
[8] 尚红,王毓三,申子瑜.全国临床检验操作规程
[S].4版.北京:人民卫生出版社,2015:184.SHANG Hong, WANG Yusan, SHEN Ziyu. National guide to clinical laboratory procedures
[S]. 4th Ed.Beijing: People’s Medical Publishing House,2015:184.
[9] 中华医学会呼吸病学分会.支气管肺泡灌洗液细胞学检测技术规范(草案)
[J].中华结核和呼吸杂志, 2002, 25(7): 390-391. Chinese Thoracic Society.Technical specification for cytological examination of bronchoalveolar lavage fluid (Draft)
[J]. Chin J Tuberc Respir Dis,2002,25(7):390-391.
[10] 刘成玉,罗春丽.临床检验基础
[M].5版.北京:人民卫生出版社, 2014:258-266.LIU Chengyu, LUO Chunli. Foundation clinical laboratory medicine
[M].5th Ed. Beijing: People’s Medical Publishing House,2014:258-266.
[11] 陈甜花,李娟,黄回滨,张晶,张福辉.血细胞参数在儿童社区获得性肺炎中的诊断价值分析
[J].中国卫生标准管理, 2021, 12(17):41-45.
[12] 黄斌,麦世龙.CRP、WBC与血细胞形态学联合检测在儿童肺炎早期诊断的应用
[J].深圳中西医结合杂志,2016, 26(21):63-64.
[13] 蒲荣,周小棉.气溶胶和飞沫将是肺部感染诊断的新标本
[J].实用医学杂志,2020,36(13):1697-1699.
[14] Metlay JP,Waterer GW,Long AC,et al. Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American thoracic society and infectious diseases society of America
[J]. Am J Respir Crit Care Med,2019,200(7):e45-45e67.
[15] 杨晓红,徐庆雷,马小波,张巍,刘玲玲,王加平.老年哮喘患者支气管肺泡灌洗液中粒细胞巨噬细胞集落刺激因子水平变化及意义
[J].现代检验医学杂志,2016,31(06):70-73.
[16] 陈晖,王胜昱,刘松,杨琳.血清和支气管肺泡灌洗液IL-6、IL-8与老年社区获得性肺炎患者预后的相关性研究
[J].国际呼吸杂志,2021,41(24):1848-1853.
[17] 张杜超,刘佳,伍江平,黄爱本,潘磊.支气管肺泡灌洗液淋巴细胞亚群对肺部病变的诊断意义
[J].标记免疫分析与临床,2021,28(04):554-557+595.
[18] 彭守春,李振华,康健,侯显明,于润江.支气管肺泡灌洗液细胞类型与特发性肺纤维化预后的关联性研究
[J].中华结核和呼吸杂志,2008(04):260-263.
[19] 孙亚红, 支气管肺泡灌洗液在慢性咳嗽患者诊断价值相关性研究. 浙江省,海宁市人民医院,2017-12-23.
[20] Mund E, Christensson B, Larsson K, Grönneberg R. Sex dependent differences in physiological ageing in the immune system of lower airways in healthy non-smoking volunteers: study of lymphocyte subsets in bronchoalveolar lavage fluid and blood. Thorax. 2001 Jun;56(6):450-5.
[21] Kikawada M, Oyama T, Ogawa K, Arai H, Iwamoto T, Takasaki M. The characterization of bronchoalveolar lavage fluid in very elderly patients with cerebrovascular disease. J Gerontol A Biol Sci Med Sci. 2001 Dec; 56(12): M771-4.
[22] 王荣英. 儿童难治性肺炎支原体肺炎血清及支气管肺泡灌洗液淋巴细胞亚群检测的研究
[D].沈阳医学院,2021.
[23] Ratjen F, Bredendiek M, Zheng L, Brendel M, Costabel U. Lymphocyte subsets in bronchoalveolar lavage fluid of children without bronchopulmonary disease. Am J Respir Crit Care Med. 1995 Jul;152(1):174-8.
[24] Selimovic A, Mujicic E, Milisic S, et al. The Significance of Bronchoalveolar Lavage Fluid Cytology in Diagnosing Lung Infiltrates in Children.Med Arch. 2016;70(1):27-30. doi:10.5455/medarh.2016.70.27-30
[25] 徐健,周道银,俞靖龙,唐古生.支气管肺泡灌洗液常规细胞形态学检查的临床应用价值评价
[J].检验医学,2012, 27(03):221-224.
[26] 张望,伍勇.肺泡灌洗液中白细胞分类计数和白介素6检测对社区获得性肺炎的诊断价值
[J].实用预防医学,2019, 26(10):1271-1273.

引用本文

张莹桃*,黎华连,欧红娟,蔡名娟,卢宇,谢祖林. BALF细胞形态学检查与外周血WBC分类计数在肺部感染中的相关性研究及价值探讨 [J]. 国际医学与数据杂志. 2025; 9; (2). 92 - 92.

文献评论

相关学者

相关机构