Neurofeedback during Eating: A Potential Novel and Mechanistic Treatment for Bulimia Nervosa-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

Neurofeedback during Eating: A Potential Novel and Mechanistic Treatment for Bulimia Nervosa

Neurofeedback during Eating: A Potential Novel and Mechanistic Treatment for Bulimia Nervosa

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DOI	10.20900/jpbs.20240007
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2024, 9(5)
作者	Laura A. Berner*,Jessica L. Qiu,Anusha Phadnis,Muhammad A. Parvaz,Michael Lührs,Siyi Lou,
作者单位	Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ; Department of Cognitive Neuroscience, Maastricht University, Maastricht 6229 ER, Netherlands ;
摘要	Bulimia nervosa (BN) is a disabling eating disorder that is associated with costly medical morbidity and often follows a chronic course. Novel treatments are needed, particularly those that directly target symptom-maintaining mechanisms. One such mechanism may be reduced activation of the prefrontal cortex (PFC) during attempts to control behavioral responses. In this proof-of-principle project, we propose to develop, establish feasibility, and preliminarily test a novel neurofeedback procedure that is intended to increase PFC activation and enhance the ability to control the consumption of common binge foods. We will compare the effects of one session of real and sham neurofeedback during eating on neural activation, inhibitory control, and clinical symptoms in women with BN. To our knowledge, this will be the first test of neurofeedback in BN to date. Results will establish this new technique’s potential to clarify causal mechanisms of BN symptoms and inform future clinical trials. Trial Registration: NCT05614024.
Abstract	Bulimia nervosa (BN) is a disabling eating disorder that is associated with costly medical morbidity and often follows a chronic course. Novel treatments are needed, particularly those that directly target symptom-maintaining mechanisms. One such mechanism may be reduced activation of the prefrontal cortex (PFC) during attempts to control behavioral responses. In this proof-of-principle project, we propose to develop, establish feasibility, and preliminarily test a novel neurofeedback procedure that is intended to increase PFC activation and enhance the ability to control the consumption of common binge foods. We will compare the effects of one session of real and sham neurofeedback during eating on neural activation, inhibitory control, and clinical symptoms in women with BN. To our knowledge, this will be the first test of neurofeedback in BN to date. Results will establish this new technique’s potential to clarify causal mechanisms of BN symptoms and inform future clinical trials. Trial Registration: NCT05614024.
关键词	bulimia nervosa; neurofeedback; functional near-infrared spectroscopy; prefrontal cortex
KeyWord	bulimia nervosa; neurofeedback; functional near-infrared spectroscopy; prefrontal cortex
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参考文献
相关文献

1.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: Fouth Edition, Text Revision (DSM-IV-TR). Washington (US): American Psychiatric Association; 2000.

2.Hudson JI, Hiripi E, Pope HG, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey replication. Biol Psychiatry. 2007;61(3):348-58.

3.Keski-Rahkonen A, Hoek HW, Linna MS, Raevuori A, Sihvola E, Bulik CM, et al. Incidence and outcomes of bulimia nervosa: a nationwide population-based study. Psychol Med. 2009;39(5):823-31.

4.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: Fifth Edition (DSM-5). Washington (US): American Psychiatric Association; 2013.

5.Lampard AM, Byrne SM, McLean N, Fursland A. An evaluation of the enhanced cognitive-behavioural model of bulimia nervosa. Behav Res Ther. 2011;49(9):529-35.

6.Hampshire A, Chamberlain SR, Monti MM, Duncan J, Owen AM. The role of the right inferior frontal gyrus: inhibition and attentional control. Neuroimage. 2010;50:1313-9.

7.Meyer HC, Bucci DJ. Imbalanced Activity in the Orbitofrontal Cortex and Nucleus Accumbens Impairs Behavioral Inhibition. Curr Biol. 2016;26(20):2834-9.

8.Marsh R, Steinglass JE, Gerber AJ, O'Leary KG, Walsh BT, Peterson BS. Deficient activity in the neural systems that mediate self-regulatory control in bulimia nervosa. Arch Gen Psychiatry. 2009;66(1):1-13.

9.Marsh R, Horga G, Wang Z, Wang P, Klahr KW, Berner LA, et al. An fMRI study of self-regulatory control and conflict resolution in adolescents with bulimia nervosa. Am J Psychiatry. 2011;168(11):1210-20.

10.Skunde M, Walther S, Simon J, Wu M, Bendszus M, Herzog W, et al. Neural signature of behavioural inhibition in women with bulimia nervosa. J Psychiatr Neurosci. 2016;41(5):E69-78.

11.Li K, Jiang Y, Gong Y, Zhao W, Zhao Z, Liu X, et al. Functional near-infrared spectroscopy-informed neurofeedback: regional-specific modulation of lateral orbitofrontal activation and cognitive flexibility. Neurophotonics. 2019;6(2):025011.

12.Derosiere G, Mandrick K, Dray G, Ward T, Perrey S. NIRS-measured prefrontal cortex activity in neuroergonomics: strengths and weaknesses. Front Hum Neurosci. 2013;7:583.

13.Kohl SH, Mehler DMA, Lührs M, Thibault RT, Konrad K, Sorger B. The Potential of Functional Near-Infrared Spectroscopy-Based Neurofeedback—A Systematic Review and Recommendations for Best Practice. Front Neurosci. 2020;14:594.

14.Berner LA, Winter SR, Ayaz H, Shewokis PA, Izzetoglu M, Marsh R, et al. Altered prefrontal activation during the inhibition of eating responses in women with bulimia nervosa. Psychol Med. 2023;53(8):3580-90.

15.Milner B. Aspects of human frontal lobe function. In: Goldman-Rakic P, editor. Epilepsy and the Functional Anatomy of the Frontal Lobe. New York (US): Raven Press; 1995. p. 67-84.

16.Hare TA, Camerer CF, Rangel A. Self-control in decision-making involves modulation of the vmPFC valuation system. Science. 2009;324(5927):646-8.

17.Uher R, Murphy T, Brammer MJ, Dalgleish T, Phillips ML, Ng VW, et al. Medial prefrontal cortex activity associated with symptom provocation in eating disorders. Am J Psychiatry. 2004;161:1238-46.

18.Rösch SA, Schmidt R, Lührs M, Ehlis AC, Hesse S, Hilbert A. Evidence of fNIRS-Based Prefrontal Cortex Hypoactivity in Obesity and Binge-Eating Disorder. Brain Sci. 2021;11(1):19.

19.Keller M, Zweerings J, Klasen M, Zvyagintsev M, Iglesias J, Mendoza Quiñones R, et al. fMRI Neurofeedback-Enhanced Cognitive Reappraisal Training in Depression: A Double-Blind Comparison of Left and Right vlPFC Regulation. Front Psychiatr. 2021;12:715898.

20.Cannon R, Congedo M, Lubar J, Hutchens T. Differentiating a Network of Executive Attention: Loreta Neurofeedback in Anterior Cingulate and Dorsolateral Prefrontal Cortices. Int J Neurosci. 2009;119(3):404-41.

21.Kohl SH, Veit R, Spetter MS, Günther A, Rina A, Lührs M, et al. Real-time fMRI neurofeedback training to improve eating behavior by self-regulation of the dorsolateral prefrontal cortex: A randomized controlled trial in overweight and obese subjects. NeuroImage. 2019;191:596-609.

22.Saif MGM, Sushkova L. Clinical efficacy of neurofeedback protocols in treatment of Attention Deficit/Hyperactivity Disorder (ADHD): A systematic review. Psychiatry Res Neuroimaging. 2023;335:111723.

23.Marx AM, Ehlis AC, Furdea A, Holtmann M, Banaschewski T, Brandeis D, et al. Near-infrared spectroscopy (NIRS) neurofeedback as a treatment for children with attention deficit hyperactivity disorder (ADHD)—a pilot study. Front Hum Neurosci. 2015;8:1038.

24.Barth B, Mayer-Carius K, Strehl U, Wyckoff SN, Haeussinger FB, Fallgatter AJ, et al. A randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder. Sci Rep. 2021;11(1):1-17.

25.Schmidt J, Martin A. Neurofeedback Against Binge Eating: A Randomized Controlled Trial in a Female Subclinical Threshold Sample. Eur Eat Disord Rev. 2016;24(5):406-16.

26.Blume M, Schmidt R, Schmidt J, Martin A, Hilbert A. EEG Neurofeedback in the Treatment of Adults with Binge-Eating Disorder: a Randomized Controlled Pilot Study. Neurotherapeutics. 2022;19(1):352-65.

27.Hilbert A, Rösch SA, Petroff D, Prettin C, Lührs M, Ehlis AC, et al. Near-infrared spectroscopy and electroencephalography neurofeedback for binge-eating disorder: an exploratory randomized trial. Psychol Med. 2024;54(4):675-86.

28.Kekic M, McClelland J, Bartholdy S, Boysen E, Musiat P, Dalton B, et al. Single-Session Transcranial Direct Current Stimulation Temporarily Improves Symptoms, Mood, and Self-Regulatory Control in Bulimia Nervosa: A Randomised Controlled Trial. PLoS One. 2017;12(1):e0167606.

29.Guillaume S, Gay A, Jaussent I, Sigaud T, Billard S, Attal J, et al. Improving decision-making and cognitive impulse control in bulimia nervosa by rTMS: An ancillary randomized controlled study. Int J Eat Disord. 2018;51(9):1103-6.

30.Dunlop KA, Woodside B, Lam E, Olmsted M, Colton P, Giacobbe P, et al. Increases in frontostriatal connectivity are associated with response to dorsomedial repetitive transcranial magnetic stimulation in refractory binge/purge behaviors. Neuroimage Clin. 2015;8:611-8.

31.Downar J, Sankar A, Giacobbe P, Woodside B, Colton P. Unanticipated Rapid Remission of Refractory Bulimia Nervosa, during High-Dose Repetitive Transcranial Magnetic Stimulation of the Dorsomedial Prefrontal Cortex: A Case Report. Front Psychiatry. 2012;3:30.

32.Schmidt J, Martin A. Neurofeedback reduces overeating episodes in female restrained eaters: A randomized controlled pilot-study. Appl Psychophysiol Biofeedback. 2015;40(4):283-95.

33.Bohon C, Stice E. Reward abnormalities among women with full and subthreshold bulimia nervosa: A functional magnetic resonance imaging study. Int J Eat Disord. 2011;44(7):585-95.

34.Fairburn CG. Cognitive Behavior Therapy and Eating Disorders. New York (US): Guilford Press; 2008.

35.Byrne SM, Allen KL, Lampard AM, Dove ER, Fursland A. The factor structure of the eating disorder examination in clinical and community samples. Int J Eat Disord. 2010;43(3):260-5.

36.Black CM, Wilson GT. Assessment of eating disorders: interview versus questionnaire. Int J Eat Disord. 1996;20(1):43-50.

37.First M, Williams J, Karg R, Spitzer R. User’s Guide for the Structured Clinical Interview for DSM-5 Disorders, Research Version (SCID-5-RV). Arlington (US): American Psychiatric Association; 2015.

38.Wechsler D. Wechsler Abbreviated Scale of Intelligence--Second Edition (WASI-II). San Antonio (US): NCS Pearson; 2011.

39.Metropolitan Life Insurance Company. New weight standards for men and women. Available from: https://www.cabidigitallibrary.org/doi/full/10.5555/19601404507. Accessed on 15 Oct 2024.

40.

40.Teslovich T, Friedl E, Kostro K, Weigel J, Davidow J, Riddle M, et al. Probing behavioral responses to food: development of a food-specific go/no-go task. Psychiatr Res. 2014;219(1):166-70.

41.Meule A, Lutz A, Krawietz V, Stützer J, Vögele C, Kübler A. Food-cue affected motor response inhibition and self-reported dieting success: a pictorial affective shifting task. Front Psychol. 2014;5:216.

42.Neuhäußer AM, Bluschke A, Roessner V, Beste C. Distinct effects of different neurofeedback protocols on the neural mechanisms of response inhibition in ADHD. Clin Neurophysiol. 2023;153:111-22.

43.Deiber MP, Ammann C, Hasler R, Colin J, Perroud N, Ros T. Electrophysiological correlates of improved executive function following EEG neurofeedback in adult attention deficit hyperactivity disorder. Clin Neurophysiol. 2021;132(8):1937-46.

44.Bluschke A, Broschwitz F, Kohl S, Roessner V, Beste C. The neuronal mechanisms underlying improvement of impulsivity in ADHD by theta/beta neurofeedback. Sci Rep. 2016;6(1):31178.

45.Klomjai W, Siripornpanich V, Aneksan B, Vimolratana O, Permpoonputtana K, Tretriluxana J, et al. Effects of cathodal transcranial direct current stimulation on inhibitory and attention control in children and adolescents with attention-deficit hyperactivity disorder: A pilot randomized sham-controlled crossover study. J Psychiatr Res. 2022;150:130-41.

46.Lam SL, Criaud M, Lukito S, Westwood SJ, Agbedjro D, Kowalczyk OS, et al. Double-Blind, Sham-Controlled Randomized Trial Testing the Efficacy of fMRI Neurofeedback on Clinical and Cognitive Measures in Children With ADHD. Am J Psychiatry. 2022;179(12):947-58.

47.Wu M, Hartmann M, Skunde M, Herzog W, Friederich HC. Inhibitory control in bulimic-type eating disorders: a systematic review and meta-analysis. PLoS One. 2013;8(12):e83412.

48.Smith KE, Mason TB, Schaefer LM, Juarascio A, Dvorak R, Weinbach N, et al. Examining intra-individual variability in food-related inhibitory control and negative affect as predictors of binge eating using ecological momentary assessment. J Psychiatr Res. 2020;120:137-43.

49.Smyth JM, Wonderlich SA, Heron KE, Sliwinski MJ, Crosby RD, Mitchell JE, et al. Daily and momentary mood and stress are associated with binge eating and vomiting in bulimia nervosa patients in the natural environment. J Consult Clin Psychol. 2007;75(4):629-38.

50.Schaefer LM, Smith KE, Anderson LM, Cao L, Crosby RD, Engel SG, et al. The role of affect in the maintenance of binge-eating disorder: Evidence from an ecological momentary assessment study. J Abnorm Psychol. 2020;129(4):387.

51.Spangler DL. The Change in Eating Disorder Symptoms scale: Scale development and psychometric properties. Eat Behav. 2010;11(3):131-7.

52.Blomquist KK, Roberto CA, Barnes RD, White MA, Masheb RM, Grilo CM. Development and validation of the Eating Loss of Control Scale. Psychol Assess. 2014;26(1):77-89.

53.Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt Impulsiveness Scale. J Clin Psychol. 1995;51:768-74.

54.Martin A, Rief W, Klaiberg A, Braehler E. Validity of the Brief Patient Health Questionnaire Mood Scale (PHQ-9) in the general population. Gen Hosp Psychiatry. 2006;28(1):71-7.

55.Spielberger CD. Manual for the State-Trait Anxiety Inventory. Palo Alto (US): Consulting Psychologists Press; 1983.

56.Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: The PANAS scales. J Pers Soc Psychol. 1988;54(6):1063-70.

57.Walsh BT, Kissileff HR, Cassidy SM, Dantzic S. Eating behavior of women with bulimia. Arch Gen Psychiatry. 1989;46(1):54-8.

58.Kirsch M, Gruber I, Ruf M, Kiefer F, Kirsch P. Real-time functional magnetic resonance imaging neurofeedback can reduce striatal cue-reactivity to alcohol stimuli. Addict Biol. 2016;21(4):982-92.

59.Lubianiker N, Paret C, Dayan P, Hendler T. Neurofeedback through the lens of reinforcement learning. Trends Neurosci. 2022;45(8):579-93.

60.Foerde K, Steinglass J, Shohamy D, Walsh B. Neural mechanisms supporting maladaptive food choices in anorexia nervosa. Nat Neurosci. 2015;18(11):1571-3.

61.Broft A, Shingleton R, Kaufman J, Liu F, Kumar D, Slifstein M, et al. Striatal dopamine in bulimia nervosa: A PET imaging study. Int J Eat Disord. 2012;45(5):648-56.

62.Zimmerli E, Devlin MJ, Kissileff HR, Walsh BT. The development of satiation in bulimia nervosa. Physiol Behav. 2010;100:346-9.

63.Lührs M, Goebel R. Turbo-Satori: a neurofeedback and brain–computer interface toolbox for real-time functional near-infrared spectroscopy. Neurophotonics. 2017;4(4):041504.

64.Li K, Yang J, Becker B, Li X. Functional near-infrared spectroscopy neurofeedback of dorsolateral prefrontal cortex enhances human spatial working memory. Neurophotonics. 2023;10(2):025011.

65.Yang X, Zeng Y, Jiao G, Gan X, Linden D, Hernaus D, et al. A brief real-time fNIRS-informed neurofeedback training of the prefrontal cortex changes brain activity and connectivity during subsequent working memory challenge. Prog Neuropsychopharmacol Biol Psychiatry. 2024;132:110968.

66.Hudak J, Blume F, Dresler T, Haeussinger FB, Renner TJ, Fallgatter AJ, et al. Near-Infrared Spectroscopy-Based Frontal Lobe Neurofeedback Integrated in Virtual Reality Modulates Brain and Behavior in Highly Impulsive Adults. Front Hum Neurosci. 2017;11:425.

67.Hadigan CM, Kissileff HR, Walsh BT. Patterns of food selection during meals in women with bulimia. Am J Clin Nutr. 1989;50(4):759-66.

68.Rosen JC, Leitenberg H, Fisher C, Khazam C. Binge‐eating episodes in bulimia nervosa: The amount and type of food consumed. Int J Eat Disord. 1986;5(2):255-67.

69.Kissileff HR, Walsh BT, Kral JG, Cassidy SM. Laboratory studies of eating behavior in women with bulimia. Physiol Behav. 1986;38:563-70.

70.LaChaussee JL, Kissileff HR, Walsh BT, Hadigan CM. The single-item meal as a measure of binge-eating behavior in patients with bulimia nervosa. Physiol Behav. 1992;51(3):593-600.

71.Anderson DA, Williamson DA, Johnson WG, Grieve CO. Validity of test meals for determining binge eating. Eat Behav. 2001;2(2):105-12.

72.Samuels F, Zimmerli EJ, Devlin MJ, Kissileff HR, Walsh BT. The development of hunger and fullness during a laboratory meal in patients with binge eating disorder. Int J Eat Disord. 2009;42(2):125-9.

73.Smeets PAM, Dagher A, Hare TA, Kullmann S, van der Laan LN, Poldrack RA, et al. Good practice in food-related neuroimaging. Am J Clin Nutr. 2019;109(3):491-503.

引用本文

Laura A. Berner*,Jessica L. Qiu,Anusha Phadnis,Muhammad A. Parvaz,Michael Lührs,Siyi Lou. Neurofeedback during Eating: A Potential Novel and Mechanistic Treatment for Bulimia Nervosa [J]. Journal of Psychiatry and Brain Science. 2024; 9; (5). - .

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