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Microbial trash to metabolic treasure

Microbial trash to metabolic treasure

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DOI	10.1097/IN9.0000000000000067
刊名	Immunometabolism IJ
年，卷(期)	2025, 7(3)
作者	Dowdell, Alexander S.; Colgan, Sean,
作者单位	[Dowdell, Alexander S.; Colgan, Sean] Mucosal Inflammation Program and Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado, Aurora, CO, USA; [Dowdell, Alexander S.; Colgan, Sean] Department of Medicine, Rocky Mounta
摘要	In a recent Nature publication, Lesbats et al uncover the molecular fate of phagocytosed bacterial contents. The authors observed incorporation of bacterial biomolecules (amino acids, metabolites) into those of the host macrophage through stable isotope labeling and mass spectrometry. Further, the authors found that the state of the phagocytosed bacteria, living or dead, dramatically alters the macrophage’s metabolic program toward either a pro-inflammatory or a “recycling” direction, respectively. This commentary summarizes these findings and further discusses the implications of this work in a broader sense.
Abstract	In a recent Nature publication, Lesbats et al uncover the molecular fate of phagocytosed bacterial contents. The authors observed incorporation of bacterial biomolecules (amino acids, metabolites) into those of the host macrophage through stable isotope labeling and mass spectrometry. Further, the authors found that the state of the phagocytosed bacteria, living or dead, dramatically alters the macrophage’s metabolic program toward either a pro-inflammatory or a “recycling” direction, respectively. This commentary summarizes these findings and further discusses the implications of this work in a broader sense.
关键词	macrophage; phagocytosis; mTORC1; AMPK; autophagy; neutrophil; dendritic cell
KeyWord	macrophage; phagocytosis; mTORC1; AMPK; autophagy; neutrophil; dendritic cell
基金项目
页码	1-3

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引用本文

Dowdell, Alexander S.; Colgan, Sean. Microbial trash to metabolic treasure [J]. Immunometabolism. 2025; 7; (3). 1 - 3.

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