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Macrophage respiratory complex III governs immune evasion

Macrophage respiratory complex III governs immune evasion

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DOI	10.1097/IN9.0000000000000065
刊名	Immunometabolism IJ
年，卷(期)	2025, 7(3)
作者	Neumann, Marie Anne-Catherine; Frezza, Christian,
作者单位	[Neumann, Marie Anne-Catherine] Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany[Neumann, Marie An
摘要	The intricate interplay between cellular metabolism and immune function has emerged as a pivotal area of research in immunology. Macrophages, as central players in the innate immune system, exhibit remarkable metabolic flexibility that influences their activation states and functional outputs, with important implications for the pathophysiology of inflammatory diseases and cancer. A recent study by Zotta and colleagues provides new insights into the role of mitochondrial complex III (CIII) in regulating the anti-inflammatory cytokine interleukin-10 (IL-10) and its implications for tumor immunity.
Abstract	The intricate interplay between cellular metabolism and immune function has emerged as a pivotal area of research in immunology. Macrophages, as central players in the innate immune system, exhibit remarkable metabolic flexibility that influences their activation states and functional outputs, with important implications for the pathophysiology of inflammatory diseases and cancer. A recent study by Zotta and colleagues provides new insights into the role of mitochondrial complex III (CIII) in regulating the anti-inflammatory cytokine interleukin-10 (IL-10) and its implications for tumor immunity.
关键词	mitochondria; metabolism; ROS; inflammation; immune evasion; IL-10
KeyWord	mitochondria; metabolism; ROS; inflammation; immune evasion; IL-10
基金项目
页码	1-3

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引用本文

Neumann, Marie Anne-Catherine; Frezza, Christian. Macrophage respiratory complex III governs immune evasion [J]. Immunometabolism. 2025; 7; (3). 1 - 3.

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