Glucose transport in the regulation of T-cell activation: the journey may be as important as the destination-Immunometabolism-CSCIED科技核心评价数据库-手机版

Glucose transport in the regulation of T-cell activation: the journey may be as important as the destination

Glucose transport in the regulation of T-cell activation: the journey may be as important as the destination

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DOI	10.1097/IN9.0000000000000003
刊名	Immunometabolism IJ
年，卷(期)	2022, 4(3)
作者	Barger, Steven W.,
作者单位	[Barger, Steven W.] Univ Arkansas Med Sci, Dept Geriatr, Little Rock, AR 72205 USA; [Barger, Steven W.] Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA; [Barger, Steven W.] Cent Arkansas Vet Healthcare Syst, Geriatr Res Educ & C
摘要	A shift in the energy-metabolism balance from oxidative phosphorylation to glycolysis is observed in several phenomena, from oncogenesis to differentiation. And this shift is not merely an indicator of the phenotypic change-an increase in glucose delivery often drives the adaption. At first blush, it seems that any route of entry should be equivalent, as long as sufficient quantities are supplied. However, an extensive study comparing the Th17 and Th1 subtypes of T cells now suggests that similar glucose transporters may not be interchangeable. Manipulation of individual transporters, or the downstream metabolites of their substrates, may afford dampening of autoimmunity potential with some degree of precision.
Abstract	A shift in the energy-metabolism balance from oxidative phosphorylation to glycolysis is observed in several phenomena, from oncogenesis to differentiation. And this shift is not merely an indicator of the phenotypic change-an increase in glucose delivery often drives the adaption. At first blush, it seems that any route of entry should be equivalent, as long as sufficient quantities are supplied. However, an extensive study comparing the Th17 and Th1 subtypes of T cells now suggests that similar glucose transporters may not be interchangeable. Manipulation of individual transporters, or the downstream metabolites of their substrates, may afford dampening of autoimmunity potential with some degree of precision.
关键词	gene expression; glucose; glucose transporter; metabolism; T cells
KeyWord	gene expression; glucose; glucose transporter; metabolism; T cells
基金项目
页码	1-3

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Barger, Steven W.. Glucose transport in the regulation of T-cell activation: the journey may be as important as the destination [J]. Immunometabolism. 2022; 4; (3). 1 - 3.

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