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Rerouting glucose metabolism of therapeutic T-cells for cancer: live longer, perform better

Rerouting glucose metabolism of therapeutic T-cells for cancer: live longer, perform better

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DOI	10.1097/IN9.0000000000000063
刊名	Immunometabolism IJ
年，卷(期)	2025, 7(3)
作者	Dong, Zhongyi; Leavenworth, Jianmei W.,
作者单位	[Dong, Zhongyi; Leavenworth, Jianmei W.] Univ Alabama Birmingham, Dept Neurosurg, Birmingham, AL 35294 USA; [Dong, Zhongyi] Univ Alabama Birmingham, Grad Biomed Sci Program, Birmingham, AL 35294 USA; [Leavenworth, Jianmei W.] Univ Alabama Birmingham, Dept
摘要	A significant barrier to the success of adoptive cell therapies (ACTs) in cancer treatment is the inadequate persistence of T-cells following infusion. In vitro T-cell expansion is a crucial component of ACTs; therefore, preconditioning during culture may enhance their in vivo survival and therapeutic efficacy. Here, we discuss a recent article by Greg Delgoffe and colleagues that was published in Cell Metabolism in April 2025, providing evidence that pharmacologic metabolic rewiring of activated T-cells during in vitro expansion enhances their engraftment postinfusion and improves cellular immunotherapies.
Abstract	A significant barrier to the success of adoptive cell therapies (ACTs) in cancer treatment is the inadequate persistence of T-cells following infusion. In vitro T-cell expansion is a crucial component of ACTs; therefore, preconditioning during culture may enhance their in vivo survival and therapeutic efficacy. Here, we discuss a recent article by Greg Delgoffe and colleagues that was published in Cell Metabolism in April 2025, providing evidence that pharmacologic metabolic rewiring of activated T-cells during in vitro expansion enhances their engraftment postinfusion and improves cellular immunotherapies.
关键词	adoptive cell therapies; pharmacologic metabolic rewiring; pyruvate dehydrogenase kinase 1; dichloroacetate; epigenetic reprogramming; exhaustion; immune memory
KeyWord	adoptive cell therapies; pharmacologic metabolic rewiring; pyruvate dehydrogenase kinase 1; dichloroacetate; epigenetic reprogramming; exhaustion; immune memory
基金项目
页码	1-3

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引用本文

Dong, Zhongyi; Leavenworth, Jianmei W.. Rerouting glucose metabolism of therapeutic T-cells for cancer: live longer, perform better [J]. Immunometabolism. 2025; 7; (3). 1 - 3.

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