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CD38 and the mitochondrial calcium uniporter contribute to age-related hematopoietic stem cell dysfunction

CD38 and the mitochondrial calcium uniporter contribute to age-related hematopoietic stem cell dysfunction

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DOI	10.1097/IN9.0000000000000048
刊名	Immunometabolism IJ
年，卷(期)	2024, 6(4)
作者	Jankowski, Connor S. R.; Weichhart, Thomas,
作者单位	[Jankowski, Connor S. R.; Weichhart, Thomas] Med Univ Vienna, Ctr Pathobiochem & Genet, Dept Med Genet, Vienna, Austria
摘要	Hematopoietic stem cells (HSCs) are the multipotent progenitors of all immune cells. During aging, their regenerative capacity decreases for reasons that are not well understood. Recently, Song et al investigated the roles of two metabolic proteins in age-related HSC dysfunction: CD38 (a membrane-bound NADase) and the mitochondrial calcium uniporter that transports calcium into the mitochondrial matrix. They found that the interplay between these proteins is deranged in aged HSCs, contributing to their diminished renewal capacity. These findings implicate compromised nicotinamide adenine dinucleotide metabolism as underlying HSC dysfunction in aging.
Abstract	Hematopoietic stem cells (HSCs) are the multipotent progenitors of all immune cells. During aging, their regenerative capacity decreases for reasons that are not well understood. Recently, Song et al investigated the roles of two metabolic proteins in age-related HSC dysfunction: CD38 (a membrane-bound NADase) and the mitochondrial calcium uniporter that transports calcium into the mitochondrial matrix. They found that the interplay between these proteins is deranged in aged HSCs, contributing to their diminished renewal capacity. These findings implicate compromised nicotinamide adenine dinucleotide metabolism as underlying HSC dysfunction in aging.
关键词	CD38; mitochondrial calcium uniporter; hematopoiesis; aging; nicotinamide adenine dinucleotide metabolism; mitochondria
KeyWord	CD38; mitochondrial calcium uniporter; hematopoiesis; aging; nicotinamide adenine dinucleotide metabolism; mitochondria
基金项目
页码	1-3

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引用本文

Jankowski, Connor S. R.; Weichhart, Thomas. CD38 and the mitochondrial calcium uniporter contribute to age-related hematopoietic stem cell dysfunction [J]. Immunometabolism. 2024; 6; (4). 1 - 3.

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