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You are what you eat: autophagy guides CD8+ T cell function through metabolism

You are what you eat: autophagy guides CD8+ T cell function through metabolism

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DOI	10.1097/IN9.0000000000000064
刊名	Immunometabolism IJ
年，卷(期)	2025, 7(3)
作者	Salgado, Caio Loureiro; Borges da Silva, Henrique,
作者单位	[Salgado, Caio Loureiro; Borges da Silva, Henrique] Mayo Clin, Dept Immunol, Phoenix, AZ 85054 USA; [Borges da Silva, Henrique] Mayo Clin, Dept Canc Biol, Phoenix, AZ 85054 USA
摘要	The differentiation of naive CD8(+) T cells into effector or memory populations requires dynamic remodeling of cellular metabolism and proteome composition. In a recent study published in Nature Immunology, Sinclair et al offer critical insights into the role of autophagy, particularly mitophagy, in regulating these processes during CD8(+) T cell differentiation. Autophagy, a conserved catabolic mechanism, is traditionally associated with cellular homeostasis and survival during nutrient deprivation. In contrast, Sinclair et al reveal that, in the immune system, autophagy is not simply a survival mechanism but a fine-tuned regulator of CD8(+) T cell metabolism and function, fine-tuning CD8(+) T cell effector vs quiescence choices.
Abstract	The differentiation of naive CD8(+) T cells into effector or memory populations requires dynamic remodeling of cellular metabolism and proteome composition. In a recent study published in Nature Immunology, Sinclair et al offer critical insights into the role of autophagy, particularly mitophagy, in regulating these processes during CD8(+) T cell differentiation. Autophagy, a conserved catabolic mechanism, is traditionally associated with cellular homeostasis and survival during nutrient deprivation. In contrast, Sinclair et al reveal that, in the immune system, autophagy is not simply a survival mechanism but a fine-tuned regulator of CD8(+) T cell metabolism and function, fine-tuning CD8(+) T cell effector vs quiescence choices.
关键词	autophagy; CD8(+) T cells; cytotoxic T cell; naive T cells; mitophagy
KeyWord	autophagy; CD8(+) T cells; cytotoxic T cell; naive T cells; mitophagy
基金项目
页码	1-3

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[1]. Reina-Campos M, Scharping NE, Goldrath AW. CD8(+) T cell metabolism in infection and cancer. Nat Rev Immunol. 2021;21(11):718-38.

[2]. Wang W, Green M, Choi JE, et al. CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569(7755):270-4.

[3]. Xu X, Araki K, Li S, et al. Autophagy is essential for effector CD8(+) T cell survival and memory formation. Nat Immunol. 2014;15(12):1152-61.

[4]. Pua HH, Dzhagalov I, Chuck M, et al. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med. 2007;204(1):25-31.

[5]. DeVorkin L, Pavey N, Carleton G, et al. Autophagy regulation of metabolism is required for CD8(+) T cell anti-tumor immunity. Cell Rep. 2019;27(2):502-13.e5.

[6]. Alsaleh G, Panse I, Swadling L, et al. Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses. Elife. 2020;9:e57950.

[7]. Sinclair LV, Youdale T, Spinelli L, et al. Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells. Nat Immunol. 2025;26(3):429-43.

[8]. Loos B, du Toit A, Hofmeyr JH. Defining and measuring autophagosome flux-concept and reality. Autophagy. 2014;10(11):2087-96.

[9]. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition),. Autophagy. 2021;17(1):1-382.

[10]. Dikic I. Proteasomal and autophagic degradation systems. Annu Rev Biochem. 2017;86:193-224.

[11]. Sena LA, Li S, Jairaman A, et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity. 2013;38(2):225-36.

[12]. Guo C, You Z, Shi H, et al. SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity. Nature. 2023;620(7972):200-8.

[13]. Ham H, Hirdler JB, Bihnam DT, et al. Lysosomal NKG7 restrains mTORC1 activity to promote CD8(+) T cell durability and tumor control. Nat Commun. 2025;16(1):1628.

[14]. Denk D, Petrocelli V, Conche C, et al. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity. 2022;55(11):2059-73.e8.,

引用本文

Salgado, Caio Loureiro; Borges da Silva, Henrique. You are what you eat: autophagy guides CD8+ T cell function through metabolism [J]. Immunometabolism. 2025; 7; (3). 1 - 3.

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