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MicroRNA-regulated B cells in obesity

MicroRNA-regulated B cells in obesity

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DOI	10.1097/IN9.0000000000000005
刊名	Immunometabolism IJ
年，卷(期)	2022, 4(3)
作者	Matz, Alyssa J.; Qu, Lili; Karlinsey, Keaton; Zhou, Beiyan,
作者单位	[Matz, Alyssa J.; Qu, Lili; Karlinsey, Keaton; Zhou, Beiyan] Univ Connecticut, Sch Med, Dept Immunol, Farmington, CT 06269 USA; [Zhou, Beiyan] Univ Connecticut, Inst Syst Genom, Farmington, CT USA
摘要	Obesity is a prevalent health risk by inducing chronic, low-grade inflammation and insulin resistance, in part from adipose tissue inflammation perpetuated by activated B cells and other resident immune cells. However, regulatory mechanisms controlling B-cell actions in adipose tissue remain poorly understood, limiting therapeutic innovations. MicroRNAs are potent regulators of immune cell dynamics through fine-tuning a network of downstream genes in multiple signaling pathways. In particular, miR-150 is crucial to B-cell development and suppresses obesity-associated inflammation via regulating adipose tissue B-cell function. Herein, we review the effect of microRNAs on B-cell development, activation, and function and highlight miR-150-regulated B-cell actions during obesity which modulate systemic inflammation and insulin resistance. In this way, we hope to promote translational discoveries that mitigate obesity-induced health risks by targeting microRNA-regulated B-cell actions.
Abstract	Obesity is a prevalent health risk by inducing chronic, low-grade inflammation and insulin resistance, in part from adipose tissue inflammation perpetuated by activated B cells and other resident immune cells. However, regulatory mechanisms controlling B-cell actions in adipose tissue remain poorly understood, limiting therapeutic innovations. MicroRNAs are potent regulators of immune cell dynamics through fine-tuning a network of downstream genes in multiple signaling pathways. In particular, miR-150 is crucial to B-cell development and suppresses obesity-associated inflammation via regulating adipose tissue B-cell function. Herein, we review the effect of microRNAs on B-cell development, activation, and function and highlight miR-150-regulated B-cell actions during obesity which modulate systemic inflammation and insulin resistance. In this way, we hope to promote translational discoveries that mitigate obesity-induced health risks by targeting microRNA-regulated B-cell actions.
关键词	B cell; microRNA; adipose tissue; obesity
KeyWord	B cell; microRNA; adipose tissue; obesity
基金项目
页码	1-6

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引用本文

Matz, Alyssa J.; Qu, Lili; Karlinsey, Keaton; Zhou, Beiyan. MicroRNA-regulated B cells in obesity [J]. Immunometabolism. 2022; 4; (3). 1 - 6.

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