Journal of International Psychiatry

[Abstract] Objective To explore the effect of fluoxetine on neurological function and negative emotion in the treatment of stroke and depression. Methods Eighty patients with stroke and depression in our hospital from April 2018 to June 2020 were selected as the study subjects. They were randomly divided into two groups using the number table method. Patients in the control group received medical treatment and psychological intervention, and the observation group was treated with fluoxetine on the basis of the control group. The hamilton anxiety scale (HAMA), hamilton depression scale (HAMD), national institutes of health stroke scale (NIHSS), chinese version of barthel index (BI), and simple mental state scale before treatment and after 3 months of treatment (MMSE) were compared. Results After treatment, the HAMD scores and HAMA scores of the two groups were significantly reduced, and the two scores of the observation group were significantly lower than those of the control group after treatment (P<0.05). After treatment, the MMSE score and BI score of the two groups increased, while the NIHSS score decreased. After treatment, the NIHSS score of the observation group was lower than the control group, and the MMSE score and BI score were higher than the control group, (P<0.05). Conclusion Fluoxetine can effectively relieve anxiety and depression in the treatment of stroke depression, and at the same time promote the recovery of patients neurological function, cognitive ability and activity ability.

Key words Fluoxetine; Stroke Depression; Neural Function; Negative Emotion