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Helping the helpers: polyamines help maintain helper T-cell lineage fidelity

Helping the helpers: polyamines help maintain helper T-cell lineage fidelity

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DOI	10.1097/IN9.0000000000000002
刊名	Immunometabolism IJ
年，卷(期)	2022, 4(3)
作者	Stewart, Tracy Murray; Holbert, Cassandra E.; Casero, Robert A.,
作者单位	[Stewart, Tracy Murray; Holbert, Cassandra E.; Casero, Robert A.] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21218 USA; Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA
摘要	The awareness that polyamines play a critical role in immune system regulation and function is coming into focus as the biological systems and analytical tools necessary to evaluate their roles have become available. Puleston et al have recently demonstrated that polyamine metabolism plays a central role in helper T-cell lineage determination through the production of the translational cofactor hypusinated eIF5A and faithful epigenetic regulation through proper histone acetylation. Their findings add to the rapidly growing body of data implicating properly controlled polyamine metabolism as essential for a normally functioning immune system.
Abstract	The awareness that polyamines play a critical role in immune system regulation and function is coming into focus as the biological systems and analytical tools necessary to evaluate their roles have become available. Puleston et al have recently demonstrated that polyamine metabolism plays a central role in helper T-cell lineage determination through the production of the translational cofactor hypusinated eIF5A and faithful epigenetic regulation through proper histone acetylation. Their findings add to the rapidly growing body of data implicating properly controlled polyamine metabolism as essential for a normally functioning immune system.
关键词	polyamines; spermidine; spermine; hypusine; T cells; immune; histone acetylation
KeyWord	polyamines; spermidine; spermine; hypusine; T cells; immune; histone acetylation
基金项目
页码	1-4

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引用本文

Stewart, Tracy Murray; Holbert, Cassandra E.; Casero, Robert A.. Helping the helpers: polyamines help maintain helper T-cell lineage fidelity [J]. Immunometabolism. 2022; 4; (3). 1 - 4.

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