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Tissue- and temporal-specific roles of extracellular ATP on T cell metabolism and function

Tissue- and temporal-specific roles of extracellular ATP on T cell metabolism and function

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DOI	10.1097/IN9.0000000000000025
刊名	Immunometabolism IJ
年，卷(期)	2023, 5(2)
作者	Santiago-Carvalho, Igor; Banuelos, Alma; da Silva, Henrique Borges,
作者单位	[Santiago-Carvalho, Igor; Banuelos, Alma; da Silva, Henrique Borges] Mayo Clin Arizona, Dept Immunol, Scottsdale, AZ 85259 USA
摘要	The activation and function of T cells is fundamental for the control of infectious diseases and cancer, and conversely can mediate several autoimmune diseases. Among the signaling pathways leading to T cell activation and function, the sensing of extracellular adenosine triphosphate (eATP) has been recently appreciated as an important component. Through a plethora of purinergic receptors, most prominently P2RX7, eATP sensing can induce a wide variety of processes in T cells, such as proliferation, subset differentiation, survival, or cell death. The downstream roles of eATP sensing can vary according to (a) the T cell subset, (b) the tissue where T cells are, and (c) the time after antigen exposure. In this mini-review, we revisit the recent findings on how eATP signaling pathways regulate T-cell immune responses and posit important unanswered questions on this field.
Abstract	The activation and function of T cells is fundamental for the control of infectious diseases and cancer, and conversely can mediate several autoimmune diseases. Among the signaling pathways leading to T cell activation and function, the sensing of extracellular adenosine triphosphate (eATP) has been recently appreciated as an important component. Through a plethora of purinergic receptors, most prominently P2RX7, eATP sensing can induce a wide variety of processes in T cells, such as proliferation, subset differentiation, survival, or cell death. The downstream roles of eATP sensing can vary according to (a) the T cell subset, (b) the tissue where T cells are, and (c) the time after antigen exposure. In this mini-review, we revisit the recent findings on how eATP signaling pathways regulate T-cell immune responses and posit important unanswered questions on this field.
关键词	T cells; eATP receptors; tissue damage; P2RX7; T cell memory
KeyWord	T cells; eATP receptors; tissue damage; P2RX7; T cell memory
基金项目
页码	1-6

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Santiago-Carvalho, Igor; Banuelos, Alma; da Silva, Henrique Borges. Tissue- and temporal-specific roles of extracellular ATP on T cell metabolism and function [J]. Immunometabolism. 2023; 5; (2). 1 - 6.

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