Inflammaging and fatty acid oxidation in monocytes and macrophages-Immunometabolism-CSCIED科技核心评价数据库-手机版

Inflammaging and fatty acid oxidation in monocytes and macrophages

Inflammaging and fatty acid oxidation in monocytes and macrophages

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DOI	10.1097/IN9.0000000000000038
刊名	Immunometabolism IJ
年，卷(期)	2024, 6(1)
作者	Kruglov, Victor; Jang, In Hwa; Camell, Christina D.,
作者单位	[Kruglov, Victor; Jang, In Hwa; Camell, Christina D.] Univ Minnesota, Inst Biol Aging & Metab, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA
摘要	Fatty acid oxidation (FAO), primarily known as beta-oxidation, plays a crucial role in breaking down fatty acids within mitochondria and peroxisomes to produce cellular energy and preventing metabolic dysfunction. Myeloid cells, including macrophages, microglia, and monocytes, rely on FAO to perform essential cellular functions and uphold tissue homeostasis. As individuals age, these cells show signs of inflammaging, a condition that includes a chronic onset of low-grade inflammation and a decline in metabolic function. These lead to changes in fatty acid metabolism and a decline in FAO pathways. Recent studies have shed light on metabolic shifts occurring in macrophages and monocytes during aging, correlating with an altered tissue environment and the onset of inflammaging. This review aims to provide insights into the connection of inflammatory pathways and altered FAO in macrophages and monocytes from older organisms. We describe a model in which there is an extended activation of receptor for advanced glycation end products, nuclear factor-kappa B (NF-kappa B) and the nod-like receptor family pyrin domain containing 3 inflammasome within macrophages and monocytes. This leads to an increased level of glycolysis, and also promotes pro-inflammatory cytokine production and signaling. As a result, FAO-related enzymes such as 5 ' AMP-activated protein kinase and peroxisome proliferator-activated receptor-alpha are reduced, adding to the escalation of inflammation, accumulation of lipids, and heightened cellular stress. We examine the existing body of literature focused on changes in FAO signaling within macrophages and monocytes and their contribution to the process of inflammaging.
Abstract	Fatty acid oxidation (FAO), primarily known as beta-oxidation, plays a crucial role in breaking down fatty acids within mitochondria and peroxisomes to produce cellular energy and preventing metabolic dysfunction. Myeloid cells, including macrophages, microglia, and monocytes, rely on FAO to perform essential cellular functions and uphold tissue homeostasis. As individuals age, these cells show signs of inflammaging, a condition that includes a chronic onset of low-grade inflammation and a decline in metabolic function. These lead to changes in fatty acid metabolism and a decline in FAO pathways. Recent studies have shed light on metabolic shifts occurring in macrophages and monocytes during aging, correlating with an altered tissue environment and the onset of inflammaging. This review aims to provide insights into the connection of inflammatory pathways and altered FAO in macrophages and monocytes from older organisms. We describe a model in which there is an extended activation of receptor for advanced glycation end products, nuclear factor-kappa B (NF-kappa B) and the nod-like receptor family pyrin domain containing 3 inflammasome within macrophages and monocytes. This leads to an increased level of glycolysis, and also promotes pro-inflammatory cytokine production and signaling. As a result, FAO-related enzymes such as 5 ' AMP-activated protein kinase and peroxisome proliferator-activated receptor-alpha are reduced, adding to the escalation of inflammation, accumulation of lipids, and heightened cellular stress. We examine the existing body of literature focused on changes in FAO signaling within macrophages and monocytes and their contribution to the process of inflammaging.
关键词	aging; cytokines; fatty acid oxidation; inflammaging; inflammasome; inflammation; lipid droplets; macrophages; metabolic disease; microglia; monocytes
KeyWord	aging; cytokines; fatty acid oxidation; inflammaging; inflammasome; inflammation; lipid droplets; macrophages; metabolic disease; microglia; monocytes
基金项目
页码	1-10

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引用本文

Kruglov, Victor; Jang, In Hwa; Camell, Christina D.. Inflammaging and fatty acid oxidation in monocytes and macrophages [J]. Immunometabolism. 2024; 6; (1). 1 - 10.

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