双相情感障碍患者抗氧化物的性别差异分析-国际精神病学杂志-CSCIED科技核心评价数据库-手机版

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双相情感障碍患者抗氧化物的性别差异分析

Gender differences of antioxidants in patients with bipolar disorder

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刊名	国际精神病学杂志 Journal of International Psychiatry
年，卷(期)	2022, 49(2)
作者	郭伟坚*,
作者单位	广州医科大学附属脑科医院 ;
摘要	探讨双相情感障碍患者抗氧化物的性别差异。方法根据性别将双相情感障碍患者分男性96例和女性31例两组，对临床资料和抗氧化物指标进行数据统计。结果治疗前两组患者尿酸、白蛋白、超氧化物歧化酶和情绪稳定剂、抗抑郁药的使用上差异有统计学意义（P<0.05），治疗后女性患者尿酸升高水平大于男性（F=13.977，P<0.001），女性白蛋白降低水平大于男性（F=6.463，P=0.012），治疗后尿酸与性别、抗抑郁药呈负相关，白蛋白与性别、年龄、情绪稳定剂呈负相关，SOD与年龄呈负相关。结论双相情感障碍患者治疗前后的抗氧化物存在性别差异。
Abstract	Objective To explore the gender differences of antioxidants in patients with bipolar disorder. Methods According to gender, patients with bipolar disorder were divided into 96 males and 31 females. Clinical data and antioxidant indicators were collected and statistically analyzed. Results There was significant difference in the use of uric acid, albumin, superoxide dismutase, mood stabilizer and antidepressants between the two groups before treatment (P<0.05). After treatment, the increase level of uric acid in female patients was higher than that in male patients (F=13.977, P<0.001), and the decrease level of albumin in female patients was higher than that in male patients (F=6.463, P=0.012).After treatment, uric acid was negatively correlated with gender and antidepressants, albumin was negatively correlated with gender, age and mood stabilizer, and SOD was negatively correlated with age. Conclusion There were gender differences in antioxidants in patients with bipolar disorder before and after treatment.
关键词	双相情感障碍；性别；抗氧化物
KeyWord	bipolar disorder；gender；antioxidants
基金项目
页码	199-202

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郭伟坚*. 双相情感障碍患者抗氧化物的性别差异分析 [J]. 国际精神病学杂志. 2022; 49; (2). 199 - 202.

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