| Abstract |
[Abstract] Objective To explore the relationship between thyroid hormones, adrenal cortex hormones and depression in the early postpartum period. Methods A total of 108 parturients from February 2019 to February 2021 were selected as the study subjects. The Edinburgh Postpartum Depression Scale (EPDS) were used to assess depression at 4-6 weeks postpartum, and set it as the depression and the non-depression group. The serum thyroxine levels, including thyroxine (T4), triiodothyronine (T3) and thyroid stimulating hormone (TSH) were detected. The adrenal cortex hormones, namely cortisol (Cor), serum serotonin (5-HT) levels were detected. Pearson correlation analysis was used to analyze the correlation between thyroid hormone, adrenal cortex hormone and EPDS score and serum 5-HT level. Results In 108 parturients, 36 cases of depression were detected 4 to 6 weeks after delivery, and the detection rate was 33.33%. Serum T4, T3, and TSH levels in the depression group were significantly lower than those in the non-depression group, and the difference was statistically significant (P<0.05). The level of serum Cor in the depression group was significantly higher than that of the non-depressive group, and the 5-HT level was significantly lower than that of the non-depressive group, the difference was statistically significant (P<0.05). Serum T4, T3, TSH levels are negatively correlated with EPDS scores, and positively correlated with 5-HT levels (P<0.05). Serum Cor is positively correlated with EPDS score, and negatively correlated with 5-HT level. Conclusion In the early postpartum period, thyroid hormones and adrenal cortex hormones have a certain relationship with the degree of depression, and may produce depression symptoms by affecting the level of 5-HT.
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