Journal of International Psychiatry

[Abstract] Objective: To study the effects of subanesthetic dose of ketamine on pain degree and anxiety in elderly patients with extensive burn. Methods: A total of 119 elderly patients with large area burns in our department from January 2019 to September 2020 were selected and divided into control group and observation group by random number table method. In the control group, 59 patients were given kefen + fentanyl + dexmedetomidine hydrochloride for analgesia. 60 patients in the observation group were treated with kefen + fentanyl + ketamine + dexmedetomidine hydrochloride for analgesia, and the anxiety and pain status, stress reaction and incidence of adverse reactions were compared before and after dressing change. Results: There were no significant differences in self-rating anxiety Scale (SAS) and visual analog scale (VAS) between the two groups 15min before dressing change (P > 0.05). SAS and VAS scores in observation group were lower than those in control group 15min after dressing change (P < 0.05). There were no significant differences in heart rate (HR), mean arterial blood pressure (MAP) and oxygen saturation (SpO2) between the two groups 15min before dressing change (P > 0.05). 15min after dressing change, MAP and SpO2 levels in observation group were higher than those in control group, while HR level was lower than that in control group (P < 0.05). There were no significant differences in the incidence of dizziness, nausea and vomiting, and pruritus between the two groups (X2=0.0005, 0.1283, 0.0002, P=0.9817, 0.7202, 0.9882 > 0.05). Conclusion: Subanesthesia dose ketamine has a definite effect on elderly patients with extensive burns and bedside dressing change, which can effectively improve patients anxiety and pain state, reduce stress response, and reduce the incidence of nausea and vomiting. It has clinical promotion value.

【 Key words 】 Ketamine; Burns; Anxiety state; Stress response; analgesic