| Abstract |
【Abstract】 Objective: To explore the relationship between estradiol (E2), prolactin (PRL) and C-reactive protein (CRP) levels before and after treatment in patients with bipolar disorder (BD) depressive episodes and their relationship with curative effect.Methods:A retrospective analysis of 116 patients with BD depressive episode admitted to our hospital from September 2019 to September 2021 were included in the BD group, and they were all given conventional antidepressant treatment. In addition, the gender and age of BD patients were compatible with each other, and 58 healthy physical examination patients were selected during the same period. In the control group, the 17-item Hamilton Depression Scale (HAMD-17) was used to evaluate the curative effect of patients, and to detect the levels of E2, PRL, and CRP in the two groups. Logistic regression was used to analyze the relationship between E2, PRL, CRP levels and curative effect, and ROC curve was used to evaluate the predictive value of E2, PRL, CRP levels on curative effect. Results: TheComparison within the group, compared with before treatment, the E2 level of patients in the BD group was significantly increased after treatment (P<0.05), and the CRP level was significantly reduced (P<0.05); compared between the groups, the E2 level of patients in the BD group was significantly lower than before treatment In the control group, the CRP level was significantly higher than that in the control group (P<0.05). After treatment, the total effective rate of treatment for patients with BD depressive episode was 81.90% (95/116), and the treatment response rate was 18.10% (21/116). The univariate results showed that the gender, age, and PRL level of patients with depressive episodes of BD were not related to the efficacy (P>0.05); while the duration of the disease, the number of episodes, the degree of depression, E2 and CRP levels were related to the efficacy (P<0.05). Multivariate logistic regression analysis showed that the course of disease ≥6 months, the number of episodes ≥5, and the decrease in CRP level were all risk factors for the efficacy of BD depressive episodes (P<0.05), and the E2 level increased and the degree of depression was mild to moderate. It is a protective factor for the curative effect of patients with BD depressive episode (P<0.05). ROC results show that the AUC of E2 and CRP levels for predicting curative effect are 0.795 and 0.986, respectively, and both have certain accuracy. Conclusion: The decrease of serum E2 level and the increase of CRP level are closely related to BD depressive episodes, and the two can be used as predictors of the efficacy of BD depressive episodes.
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