The Contribution of Alternative Splicing to Sex Biases of Aging-Related Phenotypes-Advances in Geriatric Medicine and Research-CSCIED科技核心评价数据库-手机版

The Contribution of Alternative Splicing to Sex Biases of Aging-Related Phenotypes

The Contribution of Alternative Splicing to Sex Biases of Aging-Related Phenotypes

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DOI	10.20900/agmr20230001
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2023, 5(1)
作者	Eugenia C. Olesnicky*,Bridget R. Farwell,Carolin Michael,
作者单位	Department of Biology, University of Colorado Colorado Springs, 1420 Austin Bluffs Parkway, Colorado Springs, Colorado 80918, USA
Abstract	Aging-related diseases represent one of the leading public health challenges of our time. While the precise cause of many aging-related diseases remains unknown, proteins termed splicing factors have been specifically implicated in aging-related disorders, including cancer and neurodegenerative disorders such as Alzheimer’s disease and amyotrophic lateral sclerosis. Splicing factors regulate the process of alternative splicing, which is a fundamental mechanism of RNA regulation, and thus gene expression. This review will focus on what is known about how inappropriate function of splicing factors and aberrant splicing may contribute to the manifestation of aging-related disease. Importantly, many aging-related diseases also display a sex bias, and this review will explore how alternative splicing may contribute to sex biases seen in aging-related diseases. Evidence that age- and sex-biased RNA processing occurs within the heart, brain and liver, which may contribute to sex and age biases of aging-related diseases within these tissues, will be reviewed. Furthermore, recent studies have found that throughout aging and in the progression of certain age-related diseases there is a distinct sex bias in the expression of splicing factors, as well as, aberrant alternative splicing. While splicing is currently emerging as an important factor in sex-biased aging-related diseases, only a small fraction of known splicing factors have been studied with respect to their sex-specificity and roles in aging. Recent studies underscore the need for alternative splicing profiles to become a standard component of transcriptomic analyses, with sex and age being considered as important biological variables.
KeyWord	splicing; alternative splicing; RNA-binding proteins; sex-biased splicing; aging
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Eugenia C. Olesnicky*,Bridget R. Farwell,Carolin Michael. The Contribution of Alternative Splicing to Sex Biases of Aging-Related Phenotypes, Advances in Geriatric Medicine and Research. 2023; 5; (1). https://doi.org/10.20900/agmr20230001.

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