Role of Estrogen Receptor α in Aging and Chronic Disease-Advances in Geriatric Medicine and Research-CSCIED科技核心评价数据库-手机版

Role of Estrogen Receptor α in Aging and Chronic Disease

Role of Estrogen Receptor α in Aging and Chronic Disease

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DOI	10.20900/agmr20230005
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2023, 5(2)
作者	José V. V. Isola,Sunghwan Ko,Sarah R. Ocañas,Michael B. Stout*,
作者单位	1 Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; 2 Genes & Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; 3 Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA
Abstract	Estrogen receptor alpha (ERα) plays a crucial role in reproductive function in both sexes. It also mediates cellular responses to estrogens in multiple nonreproductive organ systems, many of which regulate systemic metabolic homeostasis and inflammatory processes in mammals. The loss of estrogens and/or ERα agonism during aging is associated with the emergence of several comorbid conditions, particularly in females undergoing the menopausal transition. Emerging data also suggests that male mammals likely benefit from ERα agonism if done in a way that circumvents feminizing characteristics. This has led us, and others, to speculate that tissue-specific ERα agonism may hold therapeutic potential for curtailing aging and chronic disease burden in males and females that are at high-risk of cancer and/or cardiovascular events with traditional estrogen replacement therapies. In this mini-review, we emphasize the role of ERα in the brain and liver, summarizing recent evidence that indicates these two organs systems mediate the beneficial effects of estrogens on metabolism and inflammation during aging. We also discuss how 17α-estradiol administration elicits health benefits in an ERα-dependent manner, which provides proof-of-concept that ERα may be a druggable target for attenuating aging and age-related disease burden.
KeyWord	17α-estradiol; hypothalamus; HPG axis; liver; metabolism; neuroinflammation
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José V. V. Isola,Sunghwan Ko,Sarah R. Ocañas,Michael B. Stout*. Role of Estrogen Receptor α in Aging and Chronic Disease, Advances in Geriatric Medicine and Research. 2023; 5; (2). https://doi.org/10.20900/agmr20230005.

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