DNA Methylation and Bipolar Disorder-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

DNA Methylation and Bipolar Disorder

DNA Methylation and Bipolar Disorder

ES评分 0 浏览量：583 下载量：0

DOI	10.20900/jpbs.20230012
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2023, 8(6)
作者	Zihao Yang,Sijie Zhang,Lijun Ouyang,Aijun Liao,Ying He,Zongchang Li,Xiaogang Chen*,
作者单位	1 Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha Hunan 410011, China; 2 China National Technology Institute on Mental Disorders & Hunan Key Laboratory of Psychiatry and Mental Health, Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
Abstract	Bipolar disorder (BD) is one of the major psychiatric disorders, which damages the cognition, emotion, and physical activity of patients and causes a huge financial burden on families and society. As an important epigenetic mechanism, DNA methylation is stable and reversible and has been considered to be implicated in the development of bipolar disorder through regulating gene expression. Currently, the detection of abnormal DNA methylation positions or regions in BD is mainly based on candidate genes and epigenomic-wide DNA methylation profiling. For example, many researchers have focused on abnormal DNA methylation of BD risk genes, such as COMT, SLC6A4, BDNF, and CACNA1C. In epigenomic-wide DNA methylation association studies, researchers have identified a few novel BD-associated aberrant DNA methylation positions or regions by improving experimental design, including more subjects, and using new DNA methylation detection technologies. In addition, DNA methylation editing technologies can be used to precisely manipulate DNA methylation and de-methylation in vivo or in vitro and uncover how DNA methylation affects gene transcription, which can be used to scientifically clarify the epigenetic mechanisms underlying the pathogenesis of BD in future studies.
KeyWord	bipolar disorder; DNA methylation, epigenetic mechanism, candidate gene
基金项目
页码	-

参考文献
相关文献

1. Carvalho AF, Firth J, Vieta E. Bipolar Disorder. N Engl J Med. 2020;383(1):58-66. 2. Vieta E, Berk M, Schulze TG, Carvalho AF, Suppes T, Calabrese JR, et al. Bipolar disorders. Nat Rev Dis Primers. 2018;4(1):1-16. 3. Grande I, Berk M, Birmaher B, Vieta E. Bipolar disorder. Lancet. 2016;387(10027):1561-72. 4. Kapczinski F, Magalhaes PV, Balanza-Martinez V, Dias VV, Frangou S, Gama CS, et al. Staging systems in bipolar disorder: an International Society for Bipolar Disorders Task Force Report. Acta Psychiatr Scand. 2014;130(5):354-63. 5. Ferrari AJ, Stockings E, Khoo JP, Erskine HE, Degenhardt L, Vos T, et al. The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013. Bipolar Disord. 2016;18(5):440-50. 6. Gordovez FJA, McMahon FJ. The genetics of bipolar disorder. Mol Psychiatry. 2020;25(3):544-59. 7. Rowland TA, Marwaha S. Epidemiology and risk factors for bipolar disorder. Ther Adv Psychopharmacol. 2018;8(9):251-69. 8. Marangoni C, Hernandez M, Faedda GL. The role of environmental exposures as risk factors for bipolar disorder: a systematic review of longitudinal studies. J Affect Disord. 2016;193:165-74. 9. Aldinger F, Schulze TG. Environmental factors, life events, and trauma in the course of bipolar disorder. Psychiatry Clin Neurosci. 2017 Jan;71(1):6-17. 10. Canetta SE, Bao Y, Co MDT, Ennis FA, Cruz J, Terajima M, et al. Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring. Am J Psychiatry. 2014;171(5):557-63. 11. Li E, Zhang Y. DNA methylation in mammals. Cold Spring Harb Perspect Biol. 2014;6(5):a019133. 12. Daxinger L, Whitelaw E. Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nat Rev Genet. 2012;13(3):153-62. 13. Greenberg MVC, Bourc'his D. The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol. 2019;20(10):590-607. 14. Moore LD, Le T, Fa G. DNA methylation and its basic function. Neuropsychopharmacology. 2013;38:23-38. 15. Probst AV, Dunleavy E, Almouzni G. Epigenetic inheritance during the cell cycle. Nat Rev Mol Cell Biol. 2009;10(3):192-206. 16. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99:247-57. 17. Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009;324(5929):930-5. 18. Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature. 2010;466(7310):1129-33. 19. Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, et al. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science. 2017;356(6337):eaaj2239. 20. Ren R, Horton JR, Zhang X, Blumenthal RM, Cheng X. Detecting and interpreting DNA methylation marks. Curr Opin Struct Biol. 2018;53:88-99. 21. Ng H-H, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, et al. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet. 1999;23:58-61. 22. Zemach A, McDaniel IE, Silva P, Zilberman D. Genome-wide evolutionary analysis of eukaryotic DNA methylation. Science. 2010;328(5980):916-9. 23. Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 1992;69:915-26. 24. Higuchi F, Uchida S, Yamagata H, Otsuki K, Hobara T, Abe N, et al. State-dependent changes in the expression of DNA methyltransferases in mood disorder patients. J Psychiatr Res. 2011;45(10):1295-300. 25. Dong E, Ruzicka W, Grayson D, Guidotti A. DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients. Schizophr Res. 2015;167(1-3):35-41. 26. Morris MJ, Na ES, Autry AE, Monteggia LM. Impact of DNMT1 and DNMT3a forebrain knockout on depressive-and anxiety like behavior in mice. Neurobiol Learn Mem. 2016;135:139-145. 27. Armstrong N, Mather K, Thalamuthu A, Wright M, Trollor J, Ames D, et al. Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks. Epigenomics. 2017;9(5):689-700. 28. Lu A, Quach A, Wilson J, Reiner A, Aviv A, Raj K, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging. 2019;11(2):303-327. 29. Jylhävä J, Pedersen N, Hägg S. Biological Age Predictors. EBioMedicine. 2017;21:29-36. 30. McKinney B, Lin H, Ding Y, Lewis D, Sweet R. DNA methylation evidence against the accelerated aging hypothesis of schizophrenia. NPJ Schizophr. 2017;3:13. 31. Wu X, Ye J, Wang Z, Zhao C. Epigenetic Age Acceleration Was Delayed in Schizophrenia. Schizophr Bull. 2021;47(3):803-811. 32. Voisey J, Lawford BR, Morris CP, Wockner LF, Noble EP, Young RM, et al. Epigenetic analysis confirms no accelerated brain aging in schizophrenia. NPJ Schizophr. 2017;3(1):26. 33. McKinney B, Lin H, Ding Y, Lewis D, Sweet R. DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia. Schizophr Res. 2018;196:39-44. 34. Protsenko E, Yang R, Nier B, Reus V, Hammamieh R, Rampersaud R, et al. "GrimAge," an epigenetic predictor of mortality, is accelerated in major depressive disorder. Transl Psychiatry. 2021;11(1):193. 35. Fries GR, Bauer IE, Scaini G, Wu MJ, Kazimi IF, Valvassori SS, et al. Accelerated epigenetic aging and mitochondrial DNA copy number in bipolar disorder. Transl Psychiatry. 2017;7(12):1283. 36. Wu X, Chen W, Lin F, Huang Q, Zhong J, Gao H, et al. DNA methylation profile is a quantitative measure of biological aging in children. Aging. 2019;11(22):10031-51. 37. Weiner M, Warren L, Fiedorowicz JG. Cardiovascular morbidity and mortality in bipolar disorder. Ann Clin Psychiatry. 2011;23(1):40. 38. Fries GR, Zamzow MJ, Andrews T, Pink O, Scaini G, Quevedo J. Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications. Neurosci Biobehav Rev. 2020;112:107-16. 39. Rizzo LB, Costa LG, Mansur RB, Swardfager W, Belangero SI, Grassi-Oliveira R, et al. The theory of bipolar disorder as an illness of accelerated aging: implications for clinical care and research. Neurosci Biobehav Rev. 2014;42:157-69. 40. Fries GR, Bauer IE, Scaini G, Valvassori SS, Walss-Bass C, Soares JC, et al. Accelerated hippocampal biological aging in bipolar disorder. Bipolar Disord. 2020;22(5):498-507. 41. Jeremian R, Malinowski A, Chaudhary Z, Srivastava A, Qian J, Zai C, et al. Epigenetic age dysregulation in individuals with bipolar disorder and schizophrenia. Psychiatry Res. 2022;315:114689. 42. Okazaki S, Numata S, Otsuka I, Horai T, Kinoshita M, Sora I, et al. Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder. Transl Psychiatry. 2020;10(1):129. 43. Aldinger F, Schulze T. Environmental factors, life events, and trauma in the course of bipolar disorder. Psychiatry Clin Neurosci. 2017;71(1):6-17. 44. Oblak L, van der Zaag J, Higgins-Chen A, Levine M, Boks M. A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration. Ageing Res Rev. 2021;69:101348. 45. Rusiecki J, Chen L, Srikantan V, Zhang L, Yan L, Polin M, et al. DNA methylation in repetitive elements and post-traumatic stress disorder: a case-control study of US military service members. Epigenomics. 2012;4(1):29-40. 46. Misiak B, Szmida E, Karpiński P, Loska O, Sąsiadek M, Frydecka D. Lower LINE-1 methylation in first-episode schizophrenia patients with the history of childhood trauma. Epigenomics. 2015;7(8):1275-85. 47. Li S, Zong L, Hou Y, Zhang W, Zhou L, Yang Q, et al. Altered DNA methylation of the AluY subfamily in schizophrenia and bipolar disorder. Epigenomics. 2019;11(6):581-6. 48. Li S, Yang Q, Hou Y, Jiang T, Zong L, Wang Z, et al. Hypomethylation of LINE-1 elements in schizophrenia and bipolar disorder. J Psychiatr Res. 2018;107:68-72. 49. Murphy TM, Mullins N, Ryan M, Foster T, Kelly C, McClelland R, et al. Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients. Genes Brain Behav. 2013;12(1):125-32. 50. Ceylan D, Scola G, Tunca Z, Isaacs-Trepanier C, Can G, Andreazza AC, et al. DNA redox modulations and global DNA methylation in bipolar disorder: Effects of sex, smoking and illness state. Psychiatry Res. 2018;261:589-96. 51. Liu C, Jiao C, Wang K, Yuan N. DNA Methylation and Psychiatric Disorders. Prog Mol Biol Transl Sci. 2018;157:175-232. 52. Huzayyin AA, Andreazza AC, Turecki G, Cruceanu C, Rouleau GA, Alda M, et al. Decreased global methylation in patients with bipolar disorder who respond to lithium. Int J Neuropsychopharmacol. 2014;17(4):561-9. 53. Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet. 2011;20(24):4786-96. 54. Kurdyukov S, Bullock M. DNA Methylation Analysis: Choosing the Right Method. Biology (Basel). 2016;5(1):3. 55. Lisanti S, Omar WA, Tomaszewski B, De Prins S, Jacobs G, Koppen G, et al. Comparison of methods for quantification of global DNA methylation in human cells and tissues. PLoS One. 2013;8(11):e79044. 56. Bromberg A, Bersudsky Y, Levine J, Agam G. Global leukocyte DNA methylation is not altered in euthymic bipolar patients. J Affect Disord. 2009;118(1-3):234-9. 57. Soeiro-de-Souza MG, Andreazza AC, Carvalho AF, Machado-Vieira R, Young LT, Moreno RA. Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder. Int J Neuropsychopharmacol. 2013;16(7):1505-12. 58. Burghardt K, Goodrich J, Dolinoy D, Ellingrod V. DNA methylation, insulin resistance and second-generation antipsychotics in bipolar disorder. Epigenomics. 2015;7(3):343-52. 59. Backlund L, Wei YB, Martinsson L, Melas PA, Liu JJ, Mu N, et al. Mood Stabilizers and the Influence on Global Leukocyte DNA Methylation in Bipolar Disorder. Mol Neuropsychiatry. 2015;1(2):76-81. 60. Barros-Silva D, Marques CJ, Henrique R, Jeronimo C. Profiling DNA Methylation Based on Next-Generation Sequencing Approaches: New Insights and Clinical Applications. Genes (Basel). 2018;9(9):429. 61. Li S, Tollefsbol TO. DNA methylation methods: Global DNA methylation and methylomic analyses. Methods. 2021;187:28-43. 62. Mansell G, Gorrie-Stone TJ, Bao Y, Kumari M, Schalkwyk LS, Mill J, et al. Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array. BMC Genomics. 2019;20(1):1-15. 63. Laird PW. Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet. 2010;11(3):191-203. 64. Karemaker ID, Vermeulen M. Single-Cell DNA Methylation Profiling: Technologies and Biological Applications. Trends Biotechnol. 2018;36(9):952-65. 65. Ho AM, Winham SJ, Armasu SM, Blacker CJ, Millischer V, Lavebratt C, et al. Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder. J Psychiatr Res. 2019;117:45-54. 66. Bundo M, Ueda J, Nakachi Y, Kasai K, Kato T, Iwamoto K. Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorder. Mol Psychiatry. 2021;26(7):3407-18. 67. de Witte LD, Wang Z, Snijders G, Mendelev N, Liu Q, Sneeboer MAM, et al. Contribution of Age, Brain Region, Mood Disorder Pathology, and Interindividual Factors on the Methylome of Human Microglia. Biol Psychiatry. 2022;91(6):572-81. 68. Hesam-Shariati S, Overs BJ, Roberts G, Toma C, Watkeys OJ, Green MJ, et al. Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder. Transl Psychiatry. 2022;12(1):310. 69. Marie-Claire C, Courtin C, Bellivier F, Scott J, Etain B. Methylomic Biomarkers of Lithium Response in Bipolar Disorder: A Proof of Transferability Study. Pharmaceuticals. 2022;15(2):133. 70. Chen C, Zhang C, Cheng L, Reilly JL, Bishop JR, Sweeney JA, et al. Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia. Bipolar Disord. 2014;16(8):790-9. 71. Perroud N, Zewdie S, Stenz L, Adouan W, Bavamian S, Prada P, et al. Methylation of Serotonin Receptor 3a in Adhd, Borderline Personality, and Bipolar Disorders: Link with Severity of the Disorders and Childhood Maltreatment. Depress Anxiety. 2016;33(1):45-55. 72. Jia YF, Choi Y, Ayers-Ringler JR, Biernacka JM, Geske JR, Lindberg DR, et al. Differential SLC1A2 Promoter Methylation in Bipolar Disorder With or Without Addiction. Front Cell Neurosci. 2017;11:217. 73. Ruzicka WB, Subburaju S, Benes FM. Circuit- and Diagnosis-Specific DNA Methylation Changes at gamma-Aminobutyric Acid-Related Genes in Postmortem Human Hippocampus in Schizophrenia and Bipolar Disorder. JAMA Psychiatry. 2015;72(6):541-51. 74. Dell'Osso B, D'Addario C, Carlotta Palazzo M, Benatti B, Camuri G, Galimberti D, et al. Epigenetic modulation of BDNF gene: differences in DNA methylation between unipolar and bipolar patients. J Affect Disord. 2014;166:330-3. 75. Schroter K, Brum M, Brunkhorst-Kanaan N, Tole F, Ziegler C, Domschke K, et al. Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder. Eur Arch Psychiatry Clin Neurosci. 2020;270(2):169-81. 76. Carlberg L, Scheibelreiter J, Hassler M, Schloegelhofer M, Schmoeger M, Ludwig B, et al. Brain-derived neurotrophic factor (BDNF)-epigenetic regulation in unipolar and bipolar affective disorder. J Affect Disord. 2014;168:399-406. 77. Stenz L, Zewdie S, Laforge-Escarra T, Prados J, La Harpe R, Dayer A, et al. BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues. Neurosci Res. 2015;91:1-7. 78. Aytac HM, Pehlivan S, Pehlivan M, Oyaci Y. Quantitative detection of methylated SOCS-1 in schizophrenia and bipolar disorder considering SOCS-1-1478CA/del polymorphism and clinical parameters. Ir J Med Sci. 2023 Apr;192(2):775-783. 79. Pal M, Ebrahimi S, Oh G, Khare T, Zhang A, Kaminsky Z, et al. High Precision DNA Modification Analysis of HCG9 in Major Psychosis. Schizophr Bull. 2016;42(1):170-7. 80. Fries GR, Vasconcelos-Moreno MP, Gubert C, dos Santos BT, Sartori J, Eisele B, et al. Hypothalamic-pituitary-adrenal axis dysfunction and illness progression in bipolar disorder. Int J Neuropsychopharmacol. 2014;18(1): pyu043. 81. Saito T, Shinozaki G, Koga M, Tanichi M, Takeshita S, Nakagawa R, et al. Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder. J Affect Disord. 2020;272:417-22. 82. Schur RR, van Leeuwen JMC, Houtepen LC, Joels M, Kahn RS, Boks MP, et al. Glucocorticoid receptor exon 1F methylation and the cortisol stress response in health and disease. Psychoneuroendocrinology. 2018;97:182-9. 83. He Y, Vinkers CH, Houtepen LC, de Witte LD, Boks MP. Childhood Adversity Is Associated With Increased KITLG Methylation in Healthy Individuals but Not in Bipolar Disorder Patients. Front Psychiatry. 2018;9:743. 84. Starnawska A, Demontis D, Pen A, Hedemand A, Nielsen AL, Staunstrup NH, et al. CACNA1C hypermethylation is associated with bipolar disorder. Transl Psychiatry. 2016;6(6):e831. 85. Kaminsky Z, Jones I, Verma R, Saleh L, Trivedi H, Guintivano J, et al. DNA methylation and expression of KCNQ3 in bipolar disorder. Bipolar Disord. 2015;17(2):150-9. 86. Bengesser SA, Reininghaus EZ, Lackner N, Birner A, Fellendorf FT, Platzer M, et al. Is the molecular clock ticking differently in bipolar disorder? Methylation analysis of the clock gene ARNTL. World J Biol Psychiatry. 2018;19(sup2):S21-9. 87. Lesicka M, Dmitrzak-Weglarz M, Jablonska E, Wieczorek E, Kapelski P, Szczepankiewicz A, et al. Methylation of melatonin receptors in patients with unipolar and bipolar depression. Mech Ageing Dev. 2023;211:111776. 88. Abdolmaleky HM, Pajouhanfar S, Faghankhani M, Joghataei MT, Mostafavi A, Thiagalingam S. Antipsychotic drugs attenuate aberrant DNA methylation of DTNBP1 (dysbindin) promoter in saliva and post-mortem brain of patients with schizophrenia and Psychotic bipolar disorder. Am J Med Genet B. 2015;168(8):687-96. 89. Starnawska A, Demontis D, McQuillin A, O'Brien NL, Staunstrup NH, Mors O, et al. Hypomethylation of FAM63B in bipolar disorder patients. Clin Epigenetics. 2016;8:52. 90. Ashok AH, Marques TR, Jauhar S, Nour MM, Goodwin GM, Young AH, et al. The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Mol Psychiatry. 2017;22(5):666-79. 91. Berk M, Dodd S, Kauer‐Sant’anna M, Malhi G, Bourin M, Kapczinski F, et al. Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder. Acta Psychiatrica Scandinavica. 2007;116:41-9. 92. Nohesara S, Ghadirivasfi M, Mostafavi S, Eskandari M-R, Ahmadkhaniha H, Thiagalingam S, et al. DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder. J Psychiatr Res. 2011;45(11):1432-8. 93. Abdolmaleky HM, Cheng K-h, Faraone SV, Wilcox M, Glatt SJ, Gao F, et al. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet. 2006;15(21):3132-45. 94. Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet. 2008;82(3):696-711. 95. Mahmood T, Silverstone T. Serotonin and bipolar disorder. J Affect Disord. 2001;66(1):1-11. 96. Kishi T, Yoshimura R, Fukuo Y, Okochi T, Matsunaga S, Umene-Nakano W, et al. The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder. Eur Arch Psychiatry Clin Neurosci. 2013;263(2):105-18. 97. Mundo E, Walker M, Cate T, Macciardi F, Kennedy JL. The role of serotonin transporter protein gene in antidepressant-induced mania in bipolar disorder: preliminary findings. Arch Gen Psychiatry. 2001;58(6):539-44. 98. Cho H, Meira-Lima I, Cordeiro Q, Michelon L, Sham P, Vallada H, et al. Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis. Mol Psychiatry. 2005;10(8):771-81. 99. Baumer FM, Howe M, Gallelli K, Simeonova DI, Hallmayer J, Chang KD. A pilot study of antidepressant-induced mania in pediatric bipolar disorder: Characteristics, risk factors, and the serotonin transporter gene. Biol Psychiatry. 2006;60(9):1005-12. 100. Fries GR, Li Q, McAlpin B, Rein T, Walss-Bass C, Soares JC, et al. The role of DNA methylation in the pathophysiology and treatment of bipolar disorder. Neurosci Biobehav Rev. 2016;68:474-88. 101. Carrard A, Salzmann A, Malafosse A, Karege F. Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder. J Affect Disord. 2011;132(3):450-3. 102. Abdolmaleky HM, Yaqubi S, Papageorgis P, Lambert AW, Ozturk S, Sivaraman V, et al. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res. 2011;129(2-3):183-90. 103. Ghadirivasfi M, Nohesara S, Ahmadkhaniha HR, Eskandari MR, Mostafavi S, Thiagalingam S, et al. Hypomethylation of the serotonin receptor type-2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder. Am J Med Genet B. 2011;156B(5):536-45. 104. Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, et al. Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins. Transl Psychiatry. 2011;1:e24. 105. Gigante AD, Bond DJ, Lafer B, Lam RW, Young LT, Yatham LN. Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta‐analysis. Bipolar Disord. 2012;14(5):478-87. 106. Hashimoto K, Sawa A, Iyo M. Increased levels of glutamate in brains from patients with mood disorders. Biol Psychiatry. 2007;62(11):1310-6. 107. Brady Jr RO, McCarthy JM, Prescot AP, Jensen JE, Cooper AJ, Cohen BM, et al. Brain gamma‐aminobutyric acid (GABA) abnormalities in bipolar disorder. Bipolar Disord. 2013;15(4):434-9. 108. Tamura Y, Kunugi H, Ohashi J, Hohjoh H. Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol Psychiatry. 2007;12(6):593-600. 109. Veldic M, Kadriu B, Maloku E, Agis-Balboa RC, Guidotti A, Davis JM, et al. Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder. Schizophr Res. 2007;91(1-3):51-61. 110. Munkholm K, Vinberg M, Vedel Kessing L. Cytokines in bipolar disorder: a systematic review and meta-analysis. J Affect Disord. 2013;144(1-2):16-27. 111. Kaminsky Z, Tochigi M, Jia P, Pal M, Mill J, Kwan A, et al. A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. Mol Psychiatry. 2012;17(7):728-40. 112. Belvederi Murri M, Prestia D, Mondelli V, Pariante C, Patti S, Olivieri B, et al. The HPA axis in bipolar disorder: Systematic review and meta-analysis. Psychoneuroendocrinology. 2016;63:327-42. 113. Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci. 2013;16(1):33-41. 114. Klengel T, Binder E. FKBP5 allele-specific epigenetic modification in gene by environment interaction. Neuropsychopharmacology. 2015;40(1):244-6. 115. Houtepen LC, Vinkers CH, Carrillo-Roa T, Hiemstra M, van Lier PA, Meeus W, et al. Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nat Commun. 2016;7:10967. 116. Askland K, Read C, Moore J. Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission. Hum Genet. 2009;125(1):63-79. 117. Valenzuela FJ, Vera J, Venegas C, Munoz S, Oyarce S, Munoz K, et al. Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature. Int J Endocrinol. 2016;2016:2746909. 118. Oliveira T, Marinho V, Carvalho V, Magalhaes F, Rocha K, Ayres C, et al. Genetic polymorphisms associated with circadian rhythm dysregulation provide new perspectives on bipolar disorder. Bipolar Disord. 2018;20(6):515-22. 119. Hampp G, Ripperger JA, Houben T, Schmutz I, Blex C, Perreau-Lenz S, et al. Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Curr Biol. 2008;18(9):678-83. 120. Nievergelt CM, Kripke DF, Barrett TB, Burg E, Remick RA, Sadovnick AD, et al. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B. 2006;141B(3):234-241. 121. Dmitrzak-Weglarz MP, Pawlak JM, Maciukiewicz M, Moczko J, Wilkosc M, Leszczynska-Rodziewicz A, et al. Clock gene variants differentiate mood disorders. Mol Biol Rep. 2015;42(1):277-88. 122. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, et al. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet. 2004;13(21):2699-708. 123. Aberg KA, McClay JL, Nerella S, Clark S, Kumar G, Chen W, et al. Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults. JAMA Psychiatry. 2014;71(3):255-64. 124. D'Addario C, Dell'Osso B, Palazzo MC, Benatti B, Lietti L, Cattaneo E, et al. Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients with BDI and BDII. Neuropsychopharmacology. 2012;37(7):1647-55. 125. Gamazon ER, Badner JA, Cheng L, Zhang C, Zhang D, Cox NJ, et al. Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry. 2012;18(3):340-6. 126. Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019;51(5):793-803. 127. Chuang LC, Kao CF, Shih WL, Kuo PH. Pathway analysis using information from allele-specific gene methylation in genome-wide association studies for bipolar disorder. PLoS One. 2013;8(1):e53092. 128. Zhu K, Ou Yang TH, Dorie V, Zheng T, Anastassiou D. Meta-analysis of expression and methylation signatures indicates a stress-related epigenetic mechanism in multiple neuropsychiatric disorders. Transl Psychiatry. 2019;9(1):32. 129. Do C, Shearer A, Suzuki M, Terry MB, Gelernter J, Greally JM, et al. Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era. Genome Biol. 2017;18(1):120. 130. Do C, Lang CF, Lin J, Darbary H, Krupska I, Gaba A, et al. Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation. Am J Hum Genet. 2016;98(5):934-955. 131. Wu Y, Zeng J, Zhang F, Zhu Z, Qi T, Zheng Z, et al. Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. Nat Commun. 2018;9(1):918. 132. Zhou J, Chen Q, Braun PR, Perzel Mandell KA, Jaffe AE, Tan HY, et al. Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders. Proc Natl Acad Sci U S A. 2022;119(34):e2206069119. 133. Mallik S, Bandyopadhyay S. WeCoMXP: Weighted Connectivity Measure Integrating Co-Methylation, Co-Expression and Protein-Protein Interactions for Gene-Module Detection. IEEE/ACM Trans Comput Biol Bioinform. 2020;17(2):690-703. 134. Klug M, Rehli M. Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector. Epigenetics. 2006;1(3):127-30. 135. Chen Y, Dong E, Grayson DR. Analysis of the GAD1 promoter: trans-acting factors and DNA methylation converge on the 5' untranslated region. Neuropharmacology. 2011;60(7-8):1075-87. 136. Liu XS, Wu H, Ji X, Stelzer Y, Wu X, Czauderna S, et al. Editing DNA Methylation in the Mammalian Genome. Cell. 2016;167(1):233-247 e217. 137. Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, et al. Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell. 2018;172(5):979-992.e976. 138. Kantor B, Tagliafierro L, Gu J, Zamora ME, Ilich E, Grenier C, et al. Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD. Mol Ther. 2018;26(11):2638-49. 139. Lei Y, Huang YH, Goodell MA. DNA methylation and de-methylation using hybrid site-targeting proteins. Genome Biol. 2018;19(1):187.

引用本文

Zihao Yang,Sijie Zhang,Lijun Ouyang,Aijun Liao,Ying He,Zongchang Li,Xiaogang Chen*. DNA Methylation and Bipolar Disorder, Journal of Psychiatry and Brain Science. 2023; 8; (6). https://doi.org/10.20900/jpbs.20230012.

文献评论

相关学者

相关机构