Challenges in Identifying Individualized Brain Biomarkers of Late Life Depression-Advances in Geriatric Medicine and Research-CSCIED科技核心评价数据库-手机版

Challenges in Identifying Individualized Brain Biomarkers of Late Life Depression

Challenges in Identifying Individualized Brain Biomarkers of Late Life Depression

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DOI	10.20900/agmr20230010
刊名	Advances in Geriatric Medicine and Research AGMR
年，卷(期)	2023, 5(4)
作者	Kayla Hannon,Janine Bijsterbosch*,
作者单位	Department of Radiology, Washington University in St Louis, St Louis MO, 63110, USA
Abstract	Research into neuroimaging biomarkers for Late Life Depression (LLD) has identified neural correlates of LLD including increased white matter hyperintensities and reduced hippocampal volume. However, studies into neuroimaging biomarkers for LLD largely fail to converge. This lack of replicability is potentially due to challenges linked to construct variability, etiological heterogeneity, and experimental rigor. We discuss suggestions to help address these challenges, including improved construct standardization, increased sample sizes, multimodal approaches to parse heterogeneity, and the use of individualized analytical models.
KeyWord	late life depression; neuroimaging; biomarkers; personalized psychiatry
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Kayla Hannon,Janine Bijsterbosch*. Challenges in Identifying Individualized Brain Biomarkers of Late Life Depression, Advances in Geriatric Medicine and Research. 2023; 5; (4). https://doi.org/10.20900/agmr20230010.

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