Weakness Status is Differentially Associated with Time to Diabetes in Americans

Weakness Status is Differentially Associated with Time to Diabetes in Americans

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DOI 10.20900/agmr20240004
刊名
AGMR
年,卷(期) 2024, 6(3)
作者
作者单位

1 Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND 58108, USA;
2 Healthy Aging North Dakota, North Dakota State University, Fargo, ND 58102, USA;
3 Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58108, USA;
4 Department of Geriatrics, University of North Dakota, Grand Forks, ND 58202, USA;
5 Centre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, ON K1A 0K9, Canada;
6 School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1N 6N5, Canada;
7 Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia;
8 OCHIN Inc., Portland, OR 97228, USA;
9 Fargo VA Healthcare System, Fargo, ND 58102, USA

Abstract
Background: The purpose of this study was to evaluate the associations of (1) individual absolute and body size normalized weakness cut-points, and (2) the collective weakness classifications on time to diabetes in Americans.Methods: We analyzed data from 9577 adults aged at least 50-years from the Health and Retirement Study. Diabetes diagnosis was self-reported. A handgrip dynamometer measured handgrip strength (HGS). Males with HGS <35.5 kg (absolute), <0.45 kg/kg (normalized to body weight), or <1.05 kg/kg/m2 (normalized to BMI) were categorized as weak. Females were classified as weak if their HGS was <20.0 kg, <0.337 kg/kg, or <0.79 kg/kg/m2. Compounding weakness included falling below 1, 2, or all 3 cut-points.Results: Persons below the body weight normalized weakness cut-points had a 1.29 (95% confidence interval (CI): 1.15–1.47) higher hazard for incident diabetes, while those below the BMI normalized cut-points had a 1.30 (CI: 1.13–1.51) higher hazard. The association between absolute weakness and incident diabetes was insignificant (hazard ratio: 1.06; CI: 0.91–1.24). Americans below 1, 2, or all 3 collective weakness categories
KeyWord
aging; mass screening; muscle strength; muscle strength dynamometer
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Kelly Knoll,Yeong Rhee,Natasha Fillmore,Donald A. Jurivich,Justin J. Lang,Brenda M. McGrath,Grant R. Tomkinson,Ryan McGrath*. Weakness Status is Differentially Associated with Time to Diabetes in Americans, Advances in Geriatric Medicine and Research. 2024; 6; (3). https://doi.org/10.20900/agmr20240004.

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