Journal of International Psychiatry

[Abstract] Objective: To explore the value of combining paroxetine and low-frequency repetitive transcranial magnetic stimulation with psychological intervention in the treatment of depression patients with anxiety. Methods: Researchers randomly selected 80 patients diagnosed with depression by physicians in our hospital from January 2020 to January 2022, all of whom had symptoms of anxiety and depression. After admission, 40 patients in each group were divided into odd and even numbers. Patients in the control group received paroxetine treatment, while patients in the observation group received paroxetine treatment on the basis of the control group Low frequency repetitive transcranial magnetic stimulation combined with psychological intervention. Calculate the efficacy and adverse reactions of the two groups of patients after treatment. Results: After treatment with paroxetine combined with low-frequency repetitive transcranial magnetic stimulation, the anxiety scores of 40 patients in the observation group were significantly reduced compared to the control group; The scores of anxiety/somatization, despair, physical anxiety, mental anxiety, suicide, and depression in the control group were lower than those in the control group (P<0.05); The clinical efficacy recorded in the observation group was significantly higher than that in the control group (P<0.05); The incidence of adverse reactions recorded in the observation group showed no significant change compared to the control group (P>0.05). Conclusion: In the treatment of depression with anxiety symptoms, the combination of paroxetine, low-frequency repetitive transcranial magnetic stimulation, and psychological intervention can significantly improve their anxiety and depression symptoms, while ensuring the safety and effectiveness of treatment.

[Keywords] Paroxetine; Low frequency repetitive transcranial magnetic stimulation; Psychological intervention; Accompanying anxiety; Depression; Adverse reactions