Journal of International Psychiatry

[Abstract] Objective: To study factors associated with psychological health and quality of life (QoL) in women with Polycystic Ovary Syndrome (PCOS). Methods: 77 PCOS patients from Nanjing Yifu Hospital and 49 healthy women as controls were included. Biochemical indicators were measured, clinical data questionnaires were filled out, and the Beck Depression Inventory-II (BDI-II), Generalized Anxiety Disorder-7 (GAD-7), and PCOS-specific QoL scale (PCOSQ) were used. Differences between groups were compared, and Spearman correlation analysis was conducted. Results: The PCOS group had a higher incidence of emotional disorders compared to the control group (odds ratio: 3.66, P<0.05). Overall QoL negatively correlated with free androgen index (FAI), body mass index (BMI), and depression-anxiety scores (P<0.05). Multiple linear regression showed that FAI and depression scores influenced overall QoL in PCOS (P<0.05).The area under the ROC curve (AUC) of FAI combined with Triglycerides (TG) for predicting emotional disorders was 0.741 (P<0.05). Conclusion: Emotional disorders are more prevalent in PCOS patients, and excess biochemical androgens and emotional disorders significantly impact QoL. FAI combined with TG can serve as an early indicator for emotional disorders.

[Key words] : polycystic ovary syndrome; depression; anxiety; quality of life；PCOSQ