Journal of International Psychiatry

Department of Neurology, Xianyang Hospital, Yanan University; Xianyang, Shaanxi 712000Objective: To investigate the effect of escitalopram on anxiety and depression patients after acute cerebral infarction and its impact on neurological function and psychological status. Method: 95 patients with anxiety and depression after cerebral infarction in our hospital from March 2020 to October 2022 were selected and grouped according to the lottery method. 47 patients in the control group received structured psychological intervention, while 48 patients in the observation group received additional treatment with escitalopram. The psychological states of the two groups of patients were compared: Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD); Neurological function: neuron specific enolase (NSE), stromal cell derived factor-1 (SDF-1), and cone like protein-1 (VILIP-1); Self management ability: Various scores on the chronic disease self-management research measurement table. Result: After treatment, there was no statistically significant difference between the two groups in the scores of the chronic disease self-management study measurement table (P>0.05). After treatment, the HAMA, HAMD scores, NSE, and VILIP-1 levels in the observation group were lower than those in the control group, while the SDF-1 levels were higher than those in the control group, with statistical significance (P<0.05). Conclusion: Compared to structured psychological intervention, the combination of escitalopram and structured psychological intervention has a similar effect on improving self-management ability in patients with anxiety and depression after cerebral infarction, but its effect on improving neurological function and psychological state is better.

[Keywords] Escitalopram; Structural psychological intervention; Cerebral infarction; Anxiety and depression