Journal of International Psychiatry

Anorexia nervosa is a disease of loss of desire for food caused by various pathological and physiological factors. Adiponectin and leptin are proteins secreted by adipocytes, and adiponectin can regulate the neuropeptide Y (NPY) of the arcuate nucleus of the hypothalamus through the adenosine monophosphate protein kinase (AMPK) and phosphoinositide 3-kinase (PI3K) pathways. ), agouti-related peptide (AgRP), and pro-opioid melanocortin (POMC) neuronal activity regulate food intake; leptin can regulate food intake by regulating JAK2 (Janus kinase 2)-STAT3 (signal transducer and activator of transcription 3), PI3K and AMPK pathways regulate food intake by regulating the activity of hypothalamic feeding-related neurons. Current studies have found that adiponectin and leptin have a certain relationship with the pathogenesis of AN. The levels of adiponectin and leptin in the cerebrospinal fluid of patients with AN were altered compared with healthy individuals. Adiponectin and leptin may provide a new idea for the treatment of anorexia. This article reviews the mechanism of adiponectin and anorexia nervosa.

Anorexia nervosa；Adiponectin；leptin；diet