缺血性脑卒中后抑郁患者症状表现与血清IL-6、IL-1表达的关系
Relationship between symptoms and serum IL-6 and IL-1 expression in patients with depression after ischemic stroke
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2024, 51(1) |
| 作者 |
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| 作者单位 |
遂宁市第三人民医院（神经内科） ;
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| 摘要 |
【摘要】 探讨缺血性脑卒中后抑郁（Post-stroke depression,PSD）患者症状表现与血清白细胞介素-6（serum interleukin-6,IL-6）、白细胞介素-1（interleukin-1 ,IL-1）表达的关系。方法 选取并研究我院在2021年1月至2023年1月收治的120例缺血性脑卒中患者，依据汉密尔顿抑郁-17（Hamilton depression-17 ,HAMD-17）量表分为PSD组（n=50）和NPSD组（n=70）。比较两组基础资料信息，通过ROC及经多因素Logistic回归分析IL-6、IL-1表达预测缺血性PSD的价值，采用Pearson相关性分析血清IL-6、IL-1表达与HAMD-17量表的关系。结果 PSD组IL-6、IL-1水平显著高于NPSD组（P＜0.05）；经多因素Logistic回归分析证实，IL-6、IL-1高表达是影响缺血性PSD的危险因素（P＜0.05）；经ROC分析证实，血清IL-6、IL-1表达可用于缺血性PSD的预测，曲线下面积分别为0.677、0.849，均有P＜0.05；相关性分析显示，血清IL-6、IL-1表达与HAMD-17量表评分呈正相关（P＜0.05）。结论 血清IL-6、IL-1高表达是影响缺血性PSD的危险因素，同时与患者抑郁症状表现的严重程度呈正相关，对缺血性PSD可能具有一定的诊断价值。
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| Abstract |
【Abstract】Objective To investigate the relationship between symptoms and serum interleukin-6 (IL-6) and interleukin-1 (IL-1) expression in patients with post-stroke depression （PSD）.Methods A total of 120 patients with ischemic stroke admitted to our hospital from January 2021 to January 2023 were selected and studied, and divided into PSD group (n=50) and NPSD group (n=70) according to Hamilton depression-17 (HAMD-17) scale.Basic data were compared between the two groups, and the value of IL-6 and IL-1 expression in predicting ischemic PSD was analyzed by ROC and multivariate Logistic regression analysis.Pearson correlation was used to analyze the relationship between serum IL-6 and IL-1 expression and HAMD-17 scale.Results IL-6 and IL-1 levels in PSD group were significantly higher than those in NPSD group (P<0.05).Multivariate Logistic regression analysis confirmed that the high expression of IL-6 and IL-1 was a risk factor for ischemic PSD (P<0.05).ROC analysis confirmed that serum IL-6 and IL-1 expression could be used to predict ischemic PSD, and the area under the curve was 0.677 and 0.849, respectively, with P<0.05.Correlation analysis showed that the expression of serum IL-6 and IL-1 was positively correlated with the score of HAMD-17 scale (P<0.05).Conclusion The high expression of serum IL-6 and IL-1 is a risk factor for ischemic PSD, and is positively correlated with the severity of depressive symptoms, which may have a certain diagnostic value for ischemic PSD.
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| 关键词 |
【关键词】缺血性脑卒中；脑卒中后抑郁；白细胞介素-6；白细胞介素-1
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| KeyWord |
【Key words】Ischemic stroke; Post-stroke depression; Interleukin-6; Interleukin-1
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| 基金项目 |
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| 页码 |
211-214 |
彭大宴*.
缺血性脑卒中后抑郁患者症状表现与血清IL-6、IL-1表达的关系 [J].
国际精神病学杂志.
2024; 51; (1).
211 - 214.