Journal of International Psychiatry

[Abstract] Objective To explore the influencing factors of depression in lung cancer chemotherapy patients and the impact of combined depression on immune function. Methods Eighty lung cancer chemotherapy patients from January 2019 to April February 2023 were selected as the study subjects. The Hamilton Depression Scale (HAMD) was used for depression assessment, and divided into the depression group and the non depression group. The general information such as patient age and gender were collected. Logistic regression analysis were used to investigate the influencing factors of depression. The T lymphocyte levels between the depressive and non depressive groups were compared. Results Among 80 lung cancer chemotherapy patients, 32 were complicated with depression, with a detection rate of 40.00%; There were statistically significant differences in age, education level, monthly family income, TNM staging, and adverse reaction grading between the depression group and the non depression group (P<0.05). There was no statistically significant difference in gender and place of residence between the two groups (P>0.05). Logistic regression analysis showed that primary school education level, family monthly income<3000 yuan, TNM stage III-IV, and grade IV adverse reactions were the influencing factors for depression in lung cancer chemotherapy patients.The differentiation determining antigen 3+(CD3+), CD4+, CD4+/CD8+in the depression group were significantly lower than those in the non depression group, and CD8+was significantly higher than those in the non depression group (P<0.05). Conclusion The detection rate of depression in lung cancer chemotherapy patients is relatively high, and low educational level and monthly family income may increase the risk of depression. Moreover, combined depression can reduce the patients immune function.

Key words Lung Cancer; Chemotherapy; Depression State; Immunologic Function