| Abstract |
Objective To explore the contributing factors of anxiety and depression in patients with gastroesophageal reflux disease ( GERD ). Methods: 177 GERD patients were obtained in a tertiary hospital grouped as anxiety or depression group and non-anxiety or depression group for a case-control study. These variables of age, sex, course of disease, education level, marital status, BMI, smoking, drinking, hypertension, diabetes, heart disease, constipation, postprandial lying, exercise habits, laryngeal reflux and sleep quality, experiencing stress events within half a year were compared, univariate analysis was used to explore the statistical significance factors related to anxiety and depression in GERD patients, and multivariate Logistic regression analysis was used to explore the risk factors of anxiety or depression in GERD patients. Results There was no significant difference in gender, age, education level, course of disease, marital status, BMI, smoking, drinking, hypertension, diabetes, heart disease, postprandial lying and exercise habits between the two groups ( P > 0.05 ). The constipation, laryngeal reflux, sleep quality and experiencing stress events within half a year in patients with anxiety or depression were higher than those in patients without anxiety or depression ( P < 0.05 ). Logistic regression analysis confirmed that poor sleep quality and stressful events within half a year were risk factors for anxiety in patients with gastroesophageal reflux disease ( P < 0.05 ). Poor sleep quality, experiencing stressful events within half a year, laryngeal reflux and constipation were risk factors for anxiety in patients with gastroesophageal reflux disease ( P < 0.05 ). Conclusion Extraesophageal symptoms, sleep quality, stressful events within half a year and constipation are important risk factors for anxiety or depression in GERD patients, which should be paid attention to in clinical work.
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