Journal of International Psychiatry

Objective The differentially expressed plasma exosome proteins of first episode schizophrenic patients and healthy people was analyzed to screen out biomarkers closely related to early clinical diagnosis.Method Plasma samples of 15 patients with first episode schizophrenia and 45 healthy subjects were collected and secreted proteins of the two groups were extracted. TMT connecting with Mass spectrometry technique was used for protein quantitative analysis, and Maxquant software, Uniport databae and String website were used for bioinformatics analysis of differential proteins.Results Ninety-eight differentially expressed plasma exosome proteins were identified inthe first episode schizophrenic patients compared with the healthy people,92 proteins were significantly up-regulated,and 6 proteins were significantly down-regulated(P＜0.01). HSP90AA1, Proteasome subunit beta 1 and Proteasome subunit beta 2 were preliminarily screened as candidate protein markers related to schizophrenia. Conclusion Differentially expressed proteins in first-episode schizophrenia may become the protein markers related to the occurrence and development of schizophrenia.

Schizophrenia; exosome; protein marker