Journal of International Psychiatry

【Abstract】 Objective To investigate the risk factors of postoperative depression in patients undergoing cardiac valve replacement surgery under cardiopulmonary bypass (CPB). Methods 80 patients who underwent cardiac valve replacement surgery under CPB in our hospital from January 2020 to December 2022 were selected for the study. On the third day after surgery, the patient was divided into a non occurring group (SDS score ≥ 53) of 48 cases and an occurring group (SDS score<53) of 32 cases based on the Self Rating Depression Scale (SDS) score. Compare the baseline data of two groups of patients, and measure the levels of glutamate acid (Glu) in each group γ- Aminobutyric acid（ γ- Compare the concentration of Aminobutyric Acid (GABA) and predict the value of Glu and GABA levels in predicting depression through ROC and multivariate logistic regression analysis.Results There was no significant difference in baseline data between the two groups of patients (P>0.05), and Glu and GABA levels in the occurrence group were higher than those in the non occurrence group (P<0.05); Compared with the normal group, the plasma Glu and GABA concentrations in the occurrence group at T1-T4 time points were significantly increased (P<0.05); Through ROC and multivariate logistic regression analysis, it was confirmed that Glu>27.833 and GABA>174.684 are risk factors affecting depression, which can be used for predicting depression. The area under the curve is 0.957 and 0.711, respectively (P<0.05). Conclusion Elevated plasma Glu and GABA concentrations may be involved in the pathophysiological process of depression, providing reliable reference for clinical detection of depression.

【Key words】 Extracorporeal circulation; Heart valve replacement surgery; Postoperative depression; Glutamic acid; γ- aminobutyric acid