Journal of International Psychiatry

【Abstract】Objective To investigate the effect of milnapran combined with cognitive behavioral therapy on serum 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF) and sleep quality in patients with depression after mild traumatic brain injury. Methods A total of 100 patients with depression after mild craniocerebral trauma treated in our hospital from June 2020 to June 2023 were selected and divided into observation group and control group with 50 cases in each group by random number table method. The control group received cognitive behavioral therapy, and the observation group received minapram. The treatment course of both groups was 2 months. Evaluate the clinical efficacy of the two groups; before treatment and 3 months after treatment, the scores of Self-rating depression scale (SDS), Hamilton Depression Scale-17(HAMD-17), Montgomery-Asberg Depression Rating Scale (MADRS), Pittsburgh sleep quality index (PSQI) and the levels of serum 5-HT and BDNF were recorded; the adverse reactions of the two groups were recorded. Results The total effective rate of observation group was significantly higher than that of control group (P< 0.05). After treatment, the scores of SDS, HAMD-17, MADRS and PSQI of the observation group were lower than those of the control group (P< 0.05). After treatment, the levels of 5-HT and BDNF in both groups of the observation group were hihger than those of the control group (P< 0.05). There was no difference in the probability of adverse reactions between the two groups (P > 0.05). Conclusion Minapram combined with cognitive behavioral therapy can significantly reduce depressive mood and improve sleep quality in patients with mild traumatic depression, and has a high safety.

【Key words】Traumatic brain injury; Depression; Minapram; Cognitive behavioral therapy; Sleep quality