Journal of International Psychiatry

Objective To explore the cognitive functional characteristics and the relationship between glucose and lipid metabolism and social function in chronic schizophrenia, in order to provide corresponding theoretical basis for the mental rehabilitation of patients. Methods A total of 68 male patients with schizophrenia and 30 healthy controls were selected, to complete a self-made general condition questionnaire. Repeatable Battery for the Assessment of Neuro-psychological status (RBANS) to assess patients cognitive function and Personal and Social Performance Scale (PSP) on the social function of patients with schizophrenia. At the same time, the morning abdominal blood was collected to detect the indexes of glucose and lipid metabolism. Results There was no significant difference in age and years of education between the two groups (P>0.05). The scores of immediate memory, visuospatial, language, attention, delayed memory and the total score of RBANS in the study group were lower than those in the control group (P<0.01). Pearson correlation analysis showed that the PSP score of the patient group showed varying degrees of positive correlation with the total RBANS score and various factor scores (P<0.05 or P<0.01). The RBANS total score in the patient group was negatively correlated with fasting blood glucose and triglyceride levels (P<0.01). Multiple stepwise regression analysis further showed that the total score of RBANS and visual span and course of disease entered the regression equation, indicating that the total score of RBANS and visual span and course of disease could affect the social function of patients. Conclusion Chronic schizophrenia patients have varying degrees of impairment in cognitive function in various fields. The levels of fasting blood glucose and triglyceride are related to cognitive function. The cognitive function and course of disease of patients can affect social function .

schizophrenia；cognition；glucose and lipid metabolism；social function