| Abstract |
【Abstract】Objective To analyze the status and risk factors of early cognitive impairment in patients with alcohol dependence.Method A retrospective analysis from June 2021 to June 2023 in our hospital for treatment of the clinical data of 128 patients with alcohol dependence.According to the results of Mini Mental State Examination (MMSE), they were divided into cognitive impairment group (n=53) and no cognitive impairment group (n=75).Baseline data, cognitive function [space span (SS), visual memory (digit sequence (DS)), verbal memory (hopkins verbal learning test,HVLT), brief visuospatial memory test (BVMT)]. Multivariate Logistic regression was used to analyze the influencing factors of early cognitive impairment in patients with alcohol dependence.The ROC analysis daily drinking, drinking age, SS, HVLT predict early cognitive impairment in patients with alcohol dependence withdrawal value.Result Compared with the non-cognitive impairment group, the cognitive impairment group had significantly higher daily alcohol consumption, drinking years, proportion of smoking history, and proportion of sleep disorders, and significantly lower SS and HVLT (P < 0.05).Multivariate Logistic regression analysis confirmed that daily alcohol consumption, drinking years, smoking history, sleep disorders, SS, HVLT were risk factors for early cognitive impairment in patients with alcohol dependence (P < 0.05).Confirmed by ROC analysis, average daily drinking, drinking age, SS, HVLT all can be used to predict early cognitive impairment in patients with alcohol dependence withdrawal, the area under the curve were 0.801, 0.702, 0.806, 0.813, both P < 0.05.Conclusion Withdrawal with a greater incidence of early cognitive disorder in patients with alcohol dependence, triggering a risk factor for cognitive impairment, including fixed number of year of the average daily drinking, drinking, smoking, sleep disorder, SS, HVLT, further screening high-risk patients can be combined with the above factors, take timely preventive measures, improve the success rate of withdrawal.
|