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【Abstract】 Objective To observe the expression level of serum inflammatory factors in patients with depression and insomnia and explore its clinical significance.Methods A total of 112 patients with depression and insomnia admitted to our hospital from March 2021 to March 2023 were selected as the observation group, including 35 cases of mild depression, 47 cases of moderate depression and 30 cases of severe depression, and 50 healthy subjects were selected as the control group.Hamilton Depression Scale (HAMD) score and Pittsburgh Sleep Quality Index (PSQI) score were recorded. The levels of serum inflammatory factors such as interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were detected in all groups. Pearson correlation coefficient was used to test the correlation.Results HAMD scores and PSQI scores in the observation group were (22.16±5.82) scores and (15.09±2.35) scores, respectively, higher than those in the control group (6.09±0.74) scores and (7.13±2.78) scores, P < 0.05.Serum levels of IL-6, IL-1β and TNF-α in the observation group were (28.95±6.32) pg/mL, (35.82±8.37) pg/mL and (45.69±5.81) pg/mL, respectively. It was higher than that of control group (24.17±3.55) pg/mL, (30.29±3.75) pg/mL, (42.37±3.12) pg/mL, P < 0.05. There were significant differences in HAMD scores, PSQI scores and serum levels of IL-6, IL-1β and TNF-α in mild, moderate and severe groups (P < 0.05).HAMD score was positively correlated with PSQI score and serum levels of IL-6, IL-1β and TNF-α in patients with depression and insomnia (P < 0.05).Conclusion Compared with the healthy control group, the serum levels of IL-6, IL-1β and TNF-α were higher in patients with depression and insomnia, and the serum levels of inflammatory factors were correlated with the severity of depression.
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