五种精神障碍与大脑皮质厚度和表面积变化之间的因果关系:一项孟德尔随机化研究
Causal relationship between five psychiatric disorders and changes in cortical thickness and surface area: a Mendelian randomization study
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2024, 51(5) |
| 作者 |
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| 作者单位 |
西南医科大学附属医院 ;
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| 摘要 |
目的：采用两样本孟德尔随机化方法研究精神分裂症、双相情感障碍、重性抑郁障碍、孤独症谱系障碍、注意缺陷与多动障碍的发病风险与大脑皮质厚度和表面积变化之间的因果关系。方法:在精神病基因组学联盟(Psychiatric Genomics Consortium)以及UK biobank分别获取精神分裂症、双相情感障碍、重性抑郁障碍、孤独症谱系障碍、注意缺陷与多动障碍大脑的皮质厚度和表面积全基因组关联研究(Genome wide association study, GWAS)分析结果，利用逆方差加权法（inverse variance weighted, IVW）产生主要结果,并采用MR-Egger和Simple median分析方法计算补充结果，此外还进行了敏感性分析。结果：发现左侧颞横回表面积作为暴露、精神分裂症作为结果之间存在显著的遗传相关性。（βIVW=-0.158 、p＜0.001）。结论: 左侧颞横回表面积与精神分裂症存在单向因果关系（左侧颞横回表面积作为暴露）。
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| Abstract |
Objectives：Two-sample Mendelian randomization was used to investigate the causal relationship between changes in cortical thickness and surface area and risk of schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, attention deficit and hyperactivity disorder. Methods: In the Psychiatric Genomics Consortium and the UK biobank analyzed results from schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, attention deficit and hyperactivity disorder, and the Genome wide association study of cortical thickness and surface area. The inverse variance weighting method was used to produce the main results, and the inverse variance weighting method, weighted median method, MR-Egger and Simple median method with multiplicative random effect calculated the supplementary results. In addition, sensitivity analysis was also carried out. Results: A significant genetic correlation was found between the surface area of the left temporal transverse gyrus as exposure and schizophrenia as outcome. (βIVW=-0.158, p < 0.001). Conclusions: There was a unidirectional causal relationship between left transverse temporal gyrus surface area and schizophrenia (left transverse temporal gyrus surface area as exposure).
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| 关键词 |
精神障碍；孟德尔随机化分析；全基因组关联研究；大脑皮质厚度
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| KeyWord |
mental disorders；Mendelian randomization analysis；Genome wide association study；Cerebral cortical thickness
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| 基金项目 |
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| 页码 |
1380-1384 |
王安林*.
五种精神障碍与大脑皮质厚度和表面积变化之间的因果关系:一项孟德尔随机化研究 [J].
国际精神病学杂志.
2024; 51; (5).
1380 - 1384.